ArticleScientific reports2021
Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- The effects of recombinant human activated factor VII and tranexamic acid on traumatic bleeding and mortality in mice.Research and practice in thrombosis and haemostasis · 2026Article
- Article
- Therapeutic Plasma Exchange in Pediatric Intensive Care and Brief Overview of the Literature.Sisli Etfal Hastanesi tip bulteni · 2025Article
- rSIG combined with NLR in the prognostic assessment of patients with multiple injuries.Open medicine (Warsaw, Poland) · 2025Article
- Association of endotheliopathy with coagulofibrinolytic reactions and disseminated intravascular coagulation after trauma: a retrospective observational study.Scientific reports · 2024Observational
- Article
- Blood Transfusion for Major Trauma in Emergency Department.Diagnostics (Basel, Switzerland) · 2024Review
- Phenotypes of Disseminated Intravascular Coagulation.Thrombosis and haemostasis · 2024Article
- Characterization and Usefulness of Clot-Fibrinolysis Waveform Analysis in Critical Care Patients with Enhanced or Suppressed Fibrinolysis.Thrombosis and haemostasis · 2024Article
- A 3-Frontiers in immunology · 2023Article
- Association of Histones With Coagulofibrinolytic Responses and Organ Dysfunction in Adult Post-cardiac Arrest Syndrome.Frontiers in cardiovascular medicine · 2022Article
- Association of antithrombin with development of trauma-induced disseminated intravascular coagulation and outcomes.Frontiers in immunology · 2022Article
- Antithrombin activity levels for predicting long-term outcomes in the early phase of isolated traumatic brain injury.Frontiers in immunology · 2022Article
- Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis.Frontiers in medicine · 2021Article
- Impact of Lactate on Disseminated Intravascular Coagulation in Patients with Severe Trauma.Journal of emergencies, trauma, and shockArticle
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Authors and funding
30 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trauma patients die from massive bleeding due to disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype in the early phase, which transforms to DIC with a thrombotic phenotype in the late phase of trauma, contributing to the development of multiple organ dysfunction syndrome (MODS) and a consequently poor outcome. This is a sub-analysis of a multicenter prospective descriptive cross-sectional study on DIC to evaluate the effect of a DIC diagnosis on the survival probability and predictive performance of DIC scores for massive transfusion, MODS, and hospital death in severely injured trauma patients. A DIC diagnosis on admission was associated with a lower survival probability (Log Rank P < 0.001), higher frequency of massive transfusion and MODS and a higher mortality rate than no such diagnosis. The DIC scores at 0 and 3 h significantly predicted massive transfusion, MODS, and hospital death. Markers of thrombin and plasmin generation and fibrinolysis inhibition also showed a good predictive ability for these three items. In conclusion, a DIC diagnosis on admission was associated with a low survival probability. DIC scores obtained immediately after trauma predicted a poor prognosis of severely injured trauma patients.
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