Evidence map›Paper›PMID 34040085›Full record

ArticleScientific reports2021

Oxaloacetate treatment preserves motor function in SOD1

Sudheer K Tungtur, Heather M Wilkins, Robert S Rogers, Yomna Badawi, Jessica M Sage, Abdulbaki Agbas, Omar Jawdat, Richard J Barohn, Russell H Swerdlow, Hiroshi Nishimune

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Blockade of Presynaptic αNeurochemical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sudheer K Tungtur *Department of Anatomy and Cell Biology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Heather M Wilkins *Department of Neurology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Robert S RogersDepartment of Anatomy and Cell Biology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Yomna BadawiDepartment of Anatomy and Cell Biology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Jessica M SageDepartment of Basic Sciences, Kansas City University, Kansas City, MO, 64106, USA.
Abdulbaki AgbasDepartment of Basic Sciences, Kansas City University, Kansas City, MO, 64106, USA.
Omar JawdatDepartment of Neurology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Richard J BarohnDepartment of Neurology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Russell H SwerdlowDepartment of Neurology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Hiroshi NishimuneDepartment of Anatomy and Cell Biology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA. nishimun@tmig.or.jp.
University of Kansas · USKansas City University · USUniversity of Pittsburgh · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
UNDERSTANDING THE ROLE OF SMALL RNAS IN ARABIDOPSIS POLLEN DEVELOPMENTP20RR016475 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LUSHINGTON, GERALD H · 2001 to 2011
$38.1M
University of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BROOKS, WILLIAM M. · 2011 to 2020
$16.6M
Transgenic and Gener-Targeting CoreP20GM104936 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN · 2012 to 2016
$10.9M
Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Exercise-activated mechanisms reduce degeneration of aged neuromuscular junctionsR01AG051470 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MERINEY, STEPHEN D, NISHIMUNE, HIROSHI · 2015 to 2019
$1.9M
Active zone loss cause dying back neuropathy in amyotrophic lateral sclerosisR01NS078214 · NINDS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NISHIMUNE, HIROSHI · 2012 to 2016
$1.6M
NCRR NIH HHS P20 RR016475NIA NIH HHS P30 AG035982NIA NIH HHS R01 AG051470NICHD NIH HHS U54 HD090216NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM104936NINDS NIH HHS R01 NS078214
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) remains a devastating motor neuron disease with limited treatment options. Oxaloacetate treatment has a neuroprotective effect in rodent models of seizure and neurodegeneration. Therefore, we treated the ALS model superoxide dismutase 1 (SOD1)

Indexed as

Amyotrophic Lateral SclerosisAnimalsDisease Models, AnimalInflammationLongevityMiceMotor ActivityMotor NeuronsOxaloacetic AcidPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSpinal CordSuperoxide DismutaseTumor Necrosis Factor-alphaOxaloacetic AcidPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseSuperoxide DismutaseTumor Necrosis Factor-alpha

Identifiers

PMID34040085
PMCPMC8155202
OpenAlexW3165660094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.