Evidence map›Paper›PMID 34040043›Full record

Trial reportScientific reports2021

Pulmonary effects of dexmedetomidine infusion in thoracic aortic surgery under hypothermic circulatory arrest: a randomized placebo-controlled trial.

Seongsu Kim, Soo Jung Park, Sang Beom Nam, Suk-Won Song, Yeonseung Han, Sangmin Ko, Young Song

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07385898 (Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer), which is not on this map. Cited by 11 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 7 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07385898 nacompletednot on this mapstarted 2023, after this paper: background citation

Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer

TypeinterventionalSponsorThe Second Affiliated Hospital of Chongqing Medical UniversityRan2023 to 2024Enrolled64ConditionsRectal Tumors, Tumor of Sigmoid Colon, Lung Injury, Surgery, LaparoscopicArmsDexmedetomidine, Normal saline
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 7 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Seongsu KimDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Soo Jung ParkDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Sang Beom NamDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Suk-Won SongDepartment of Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, South Korea.
Yeonseung HanDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Sangmin KoDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Young SongDepartment of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea. NEARMYHEART@yuhs.ac.
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dexmedetomidine has emerged as a promising organ protective agent. We performed prospective randomized placebo-controlled trial investigating effects of perioperative dexmedetomidine infusion on pulmonary function following thoracic aortic surgery with cardiopulmonary bypass and moderate hypothermic circulatory arrest. Fifty-two patients were randomized to two groups: the dexmedetomidine group received 1 µg/kg of dexmedetomidine over 20 min after induction of anesthesia, followed by 0.5 µg/kg/h infusion until 12 h after aortic cross clamp (ACC)-off, while the control group received the same volume of normal saline. The primary endpoints were oxygenation indices including arterial O

Indexed as

Aorta, ThoracicDexmedetomidineAgedCardiopulmonary BypassCirculatory Arrest, Deep Hypothermia InducedFemaleHumansLungMaleMalondialdehydeMiddle AgedProspective StudiesDexmedetomidineMalondialdehyde

Identifiers

PMID34040043
PMCPMC8155071
OpenAlexW3165286854

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.