Evidence map›Paper›PMID 34040042›Full record

ArticleScientific reports2021

Evaluating atypical language in autism using automated language measures.

Alexandra C Salem, Heather MacFarlane, Joel R Adams, Grace O Lawley, Jill K Dolata, Steven Bedrick, Eric Fombonne

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  8. Review
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  11. Consistency and reliability of automated language measures across expressive language samples in autism.Autism research : official journal of the International Society for Autism Research · 2023
    Article
  12. ParAlg: A Paraphasia Algorithm for Multinomial Classification of Picture Naming Errors.Journal of speech, language, and hearing research : JSLHR · 2023
    Article
  13. Evaluating the Performance of Transformer-based Language Models for Neuroatypical Language.Proceedings of COLING. International Conference on Computational Linguistics · 2022
    Article
  14. Combining voice and language features improves automated autism detection.Autism research : official journal of the International Society for Autism Research · 2022
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alexandra C Salem *Department of Psychiatry, Oregon Health and Science University, Portland, 97239, USA. salem@ohsu.edu.
Heather MacFarlane *Department of Psychiatry, Oregon Health and Science University, Portland, 97239, USA.
Joel R AdamsComputer Science and Electrical Engineering, Oregon Health and Science University, Portland, 97239, USA.
Grace O LawleyComputer Science and Electrical Engineering, Oregon Health and Science University, Portland, 97239, USA.
Jill K DolataDepartment of Pediatrics, Oregon Health and Science University, Portland, 97239, USA.
Steven BedrickDepartment of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, 97239, USA.
Eric FombonneDepartment of Psychiatry, Oregon Health and Science University, Portland, 97239, USA.
Oregon Health & Science University · US

Funding

Computational characterization of language use in autism spectrum disorderR01DC012033 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI FOMBONNE, ERIC · 2011 to 2021
$6.7M
Brain trajectories in ADHDR01MH115357 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A, NIGG, JOEL T · 2017 to 2021
$3.8M
Longitudinal Imaging Study of ADHD Brain DevelopmentR01MH086654 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2010 to 2014
$2.9M
NIDCD NIH HHS R01 DC012033NIMH NIH HHS R01 MH086654NIMH NIH HHS R01 MH115357
6 · The paper itself

Abstract

Measurement of language atypicalities in Autism Spectrum Disorder (ASD) is cumbersome and costly. Better language outcome measures are needed. Using language transcripts, we generated Automated Language Measures (ALMs) and tested their validity. 169 participants (96 ASD, 28 TD, 45 ADHD) ages 7 to 17 were evaluated with the Autism Diagnostic Observation Schedule. Transcripts of one task were analyzed to generate seven ALMs: mean length of utterance in morphemes, number of different word roots (NDWR), um proportion, content maze proportion, unintelligible proportion, c-units per minute, and repetition proportion. With the exception of repetition proportion (p [Formula: see text]), nonparametric ANOVAs showed significant group differences (p[Formula: see text]). The TD and ADHD groups did not differ from each other in post-hoc analyses. With the exception of NDWR, the ASD group showed significantly (p[Formula: see text]) lower scores than both comparison groups. The ALMs were correlated with standardized clinical and language evaluations of ASD. In age- and IQ-adjusted logistic regression analyses, four ALMs significantly predicted ASD status with satisfactory accuracy (67.9-75.5%). When ALMs were combined together, accuracy improved to 82.4%. These ALMs offer a promising approach for generating novel outcome measures.

Indexed as

Natural Language ProcessingAdolescentAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderChildDiagnosis, DifferentialFemaleFunctional NeuroimagingHumansLanguage DisordersLanguage TestsLogistic ModelsMagnetic Resonance ImagingMaleModels, NeurologicalSeverity of Illness Index

Identifiers

PMID34040042
PMCPMC8155086
OpenAlexW3165069738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.