Evidence map›Paper›PMID 34040023›Full record

ArticleScientific reports2021

The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes.

Rupjyoti Talukdar, Priyanka Sarkar, Aparna Jakkampudi, Subhaleena Sarkar, Mohsin Aslam, Manasa Jandhyala, G Deepika, Misbah Unnisa, D Nageshwar Reddy

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rupjyoti TalukdarPancreas Research Group and Division of Gut Microbiome Research, Wellcome DBT India Alliance Laboratories, Institute of Basic and Translational Research, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, 500032, India. rup_talukdar@yahoo.com.
Priyanka SarkarPancreas Research Group and Division of Gut Microbiome Research, Wellcome DBT India Alliance Laboratories, Institute of Basic and Translational Research, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, 500032, India.
Aparna JakkampudiPancreas Research Group and Division of Gut Microbiome Research, Wellcome DBT India Alliance Laboratories, Institute of Basic and Translational Research, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, 500032, India.
Subhaleena SarkarPancreas Research Group and Division of Gut Microbiome Research, Wellcome DBT India Alliance Laboratories, Institute of Basic and Translational Research, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, 500032, India.
Mohsin AslamDepartment of Endocrinology, Asian Institute of Gastroenterology, Hyderabad, India.
Manasa JandhyalaPancreas Research Group and Division of Gut Microbiome Research, Wellcome DBT India Alliance Laboratories, Institute of Basic and Translational Research, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, 500032, India.
G DeepikaDepartment of Biochemistry, Asian Institute of Gastroenterology, Hyderabad, India.
Misbah UnnisaDepartment of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.
D Nageshwar ReddyDepartment of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.
Asian Institute of Gastroenterology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We hypothesized that the gut microbiome in patients with diabetes secondary to chronic pancreatitis (Type 3c) is different from those with Type 1 and Type 2 diabetes. This was a cross-sectional preliminary study that included 8 patients with Type 1, 10 with Type 2, 17 with Type 3c diabetes and 9 healthy controls. Demographic, clinical, biochemical, imaging and treatment data were recorded and sequencing of the V3-V4 region of the bacterial 16SrRNA was done on fecal samples. Bioinformatics and statistical analyses was performed to evaluate the differences in the diversity indices, distance matrices, relative abundances and uniqueness of organisms between the types of diabetes. There was significant difference in the species richness. Beta diversity was significantly different between patients with Type 3c diabetes and the other groups. 31 genera were common to all the three types of diabetes. There was significant differences in the species level taxa between Type 3c diabetes and the other groups. The unique bacterial species signature in Type 3c diabetes compared to Type 1 and Type 2 diabetes included Nesterenkonia sp. AN1, Clostridium magnum, Acinetobacter lwoffii, Clostridium septicum, Porphyromonas somerae, Terrabacter tumescens, and Synechococus sp.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Gastrointestinal MicrobiomeAdultAgedBacteriaCase-Control StudiesCross-Sectional StudiesFecesFemaleHumansMaleMiddle AgedPancreatitis, ChronicRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID34040023
PMCPMC8155207
OpenAlexW3164959959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.