Evidence map›Paper›PMID 34040017›Full record

ArticleScientific reports2021

PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma.

Linda Vidarsdottir, Alireza Azimi, Ishani Das, Ingibjorg Sigvaldadottir, Aldwin Suryo Rahmanto, Andreas Petri, Sakari Kauppinen, Christian Ingvar, Göran Jönsson, Håkan Olsson and 8 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. The Roles of PTEN in Melanoma Suppression.Pigment cell & melanoma research · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Cancers · 2023
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Linda VidarsdottirDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Alireza AzimiDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Ishani DasDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Ingibjorg SigvaldadottirDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Aldwin Suryo RahmantoDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Andreas PetriCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark.
Sakari KauppinenCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark.
Christian IngvarDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Göran JönssonDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Håkan OlssonDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Marianne Frostvik StoltDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Rainer TuominenDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Olle SangfeltDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Katja Pokrovskaja TammDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Johan HanssonDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Dan GrandérDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Suzanne Egyházi BrageDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden. suzanne.egyhazi.brage@ki.se.
Per JohnssonDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden. per.a.johnsson@ki.se.
Karolinska Institutet · SELund University · SEAalborg University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BRAF inhibitors (BRAFi) selectively target oncogenic BRAF

Indexed as

Drug Resistance, NeoplasmMelanomaProto-Oncogene Proteins B-rafPTEN PhosphohydrolaseCell Line, TumorEnhancer of Zeste Homolog 2 ProteinFemaleGene Expression Regulation, NeoplasticHumansMaleNeoplasm StagingPrognosisPromoter Regions, GeneticProtein Kinase InhibitorsRNA, AntisenseSkin NeoplasmsBRAF protein, humanEnhancer of Zeste Homolog 2 ProteinProtein Kinase InhibitorsProto-Oncogene Proteins B-rafPTEN PhosphohydrolasePTEN protein, humanRNA, Antisense

Identifiers

PMID34040017
PMCPMC8155038
OpenAlexW3164123835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.