Evidence map›Paper›PMID 34040002›Full record

ArticleScientific reports2021

Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection.

Elisabetta Pandolfi, Nadia Panera, Anna Alisi, Emanuela Carloni, Luisa Russo, Ilaria Campagna, Caterina Rizzo, Carlo Concato, Giulia Linardos, Livia Piccioni and 4 more

Registry-linked trialOpen access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05378022 (Application of LiveSpo Navax in Treatment of Acute Respiratory Disease in Children Infected With Influenza Virus), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05378022 nacompletednot on this map

Application of LiveSpo Navax in Treatment of Acute Respiratory Disease in Children Infected With Influenza Virus

TypeinterventionalSponsorNational Children's Hospital, VietnamRan2020 to 2022Enrolled70ConditionsAcute Respiratory Tract InfectionsArmsLiveSpo Navax, 0.9% NaCl physiological saline
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Elisabetta PandolfiMultifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio, 4, 00165, Rome, Italy. elisabetta.pandolfi@opbg.ne.
Nadia PaneraResearch Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.
Anna AlisiResearch Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.
Emanuela CarloniMultifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio, 4, 00165, Rome, Italy.
Luisa RussoMultifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio, 4, 00165, Rome, Italy.
Ilaria CampagnaMultifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio, 4, 00165, Rome, Italy.
Caterina RizzoMultifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio, 4, 00165, Rome, Italy.
Carlo ConcatoVirology Unit, Laboratory Department, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.
Giulia LinardosVirology Unit, Laboratory Department, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.
Livia PiccioniVirology Unit, Laboratory Department, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.
Sally JacksonMultifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio, 4, 00165, Rome, Italy.
Alberto VillaniDepartment of Pediatrics, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.
Fabio MidullaDepartment of Pediatrics, Sapienza University, Rome, Italy.
Alberto E TozziMultifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital (IRCCS), Piazza S. Onofrio, 4, 00165, Rome, Italy.
Bambino Gesù Children's Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanisms of interaction between Bordetella pertussis and other viral agents are yet to be fully explored. We studied the inflammatory cytokine expression patterns among children with both viral-bacterial infections. Nasopharyngeal aspirate (NPA) samples were taken from children, aged < 1 year, positive for Rhinovirus, Bordetella pertussis and for Rhinovirus and Bordetella pertussis. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Our results show that co-infections display a different inflammatory pattern compared to single infections, suggesting that a chronic inflammation caused by one of the two pathogens could be the trigger for exacerbation in co-infections.

Indexed as

RhinovirusAge of OnsetAnti-Bacterial AgentsCoinfectionCytokinesDisease ProgressionFamily CharacteristicsFemaleGene Expression RegulationHumansInfantInfant, NewbornInflammationInflammation MediatorsMaleNasopharynxAnti-Bacterial AgentsCytokinesInflammation Mediators

Identifiers

PMID34040002
PMCPMC8154898
OpenAlexW3164602900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.