ArticleNPJ Parkinson's disease2021
Early constipation predicts faster dementia onset in Parkinson's disease.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07786116 (Met-Pro Study), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Met-Pro Study: The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Efficacy and safety of fecal microbiota transplantation in the management of parkinson's disease: a systematic review.BMC neurology · 2025Pooled it
- Constipation and risk of cognitive impairment and dementia in adults: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Constipation prevalence and risk from prescribed medications in people with intellectual disability: Findings from an English mortality programme.Journal of intellectual disabilities : JOID · 2026Article
- Advancing Gut-Brain Axis Research in Parkinson's Disease: Addressing Measurement Heterogeneity and Baseline Cognitive Stratification.Journal of gastroenterology and hepatology · 2026Article
- Article
- Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Cumulative incidence and risk factors of dementia in Parkinson's disease and parkinsonism: a population-based study.Brain communications · 2026Article
- Efficacy of acupuncture for patients with Parkinson's disease-related constipation: study protocol for a randomized controlled, double-blind trial.Frontiers in neuroscience · 2026Article
- Investigation of the Determinants of Disease Severity in Patients with Idiopathic Normal Pressure Hydrocephalus.Movement disorders clinical practice · 2025Article
- Constipation in a Large Online Cohort of Persons with Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Discriminating between proposed Brain-First and Body-First Parkinson's disease using conventional and radiomics-enhanced dopamine transporter SPECT image analysis.NPJ Parkinson's disease · 2025Article
- Prevalence and Clinical Characteristics of Mirror Movements in a Chinese Cohort of Parkinson's Disease Patients.Annals of Indian Academy of Neurology · 2025Article
- Intestinal biomarkers, microbiota composition, and genetic predisposition to inflammatory bowel disease as predictors of Parkinson's disease manifestation.Journal of Parkinson's disease · 2025Article
- The profile of gastrointestinal dysfunction in prodromal to late-stage Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Impact of anti-VZV IgG levels on Parkinson's disease risk and progression: a Mendelian randomization analysis.Scientific reports · 2025Article
- Defecation after magnesium supplementation enhances cognitive performance in triathletes.Sports medicine and health science · 2025Article
- Investigation of nonmotor symptoms and their clinical correlates in patients with Parkinson's disease.Neurodegenerative disease management · 2025Article
- Constipation symptoms are associated with worse cognitive outcomes in older adults without dementia.Frontiers in nutrition · 2025Article
- Advances in autonomic dysfunction research in Parkinson's disease.Frontiers in aging neuroscience · 2025Review
- Systemic determinants of brain health in ageing.Nature reviews. Neurology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson's Incidence Cohorts Collaboration, composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessed with the MDS-UPDRS constipation item or a comparable categorical scale. Primary PD outcomes of interest were dementia, postural instability and death. PD patients were stratified according to constipation severity at diagnosis: none (n = 313, 67.3%), minor (n = 97, 20.9%) and major (n = 55, 11.8%). Clinical progression to all three outcomes was more rapid in those with more severe constipation at baseline (Kaplan-Meier survival analysis). Cox regression analysis, adjusting for relevant confounders, confirmed a significant relationship between constipation severity and progression to dementia, but not postural instability or death. Early constipation may predict an accelerated progression of neurodegenerative pathology.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.