Observational studyNature communications2021
Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression.
Observational study in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Menopause and suicide: A systematic review.Women's health (London, England)Pooled it
- Blunted anticipation, but not consummation, of food rewards in depression.Cell reports. Medicine · 2026Article
- The link between GABA levels and P300 abnormalities in schizophrenia spectrum disorders: regional and symptom-based insights.Schizophrenia (Heidelberg, Germany) · 2026Article
- Neurobiological and emotional impact of occupational stress in frontline police officers: a neuroimaging and neurochemical study.European journal of psychotraumatology · 2025Article
- Resiliency and Mental Health Symptoms Among Active Duty Service Members With a History of Mild Traumatic Brain Injury.Archives of rehabilitation research and clinical translation · 2025Article
- State-dependent reactivity of anterior cingulate cortex neurochemistry and downstream autonomic arousal in intrusive thinking.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Medial prefrontal glutamate response to acute stress is associated with social subordination in female rhesus macaques.Translational psychiatry · 2025Article
- Rasd2 regulates depression-like behaviors via DRD2 neurons in the prelimbic cortex afferent to nucleus accumbens core circuit.Molecular psychiatry · 2025Article
- Functional Network Connectivity for Components of Depression-Related Psychological Fragility.Brain sciences · 2024Article
- Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity.Journal of the American College of Cardiology · 2024Article
- Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents.Brain, behavior, & immunity - health · 2024Article
- JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions.Molecular biomedicine · 2023Review
- Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala.Molecular psychiatry · 2023Article
- An MR spectroscopy study of temporal areas excluding primary auditory cortex and frontal regions in subjective bilateral and unilateral tinnitus.Scientific reports · 2023Article
- The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle.Frontiers in behavioral neuroscience · 2022Article
- Environmental Contributions to Anhedonia.Current topics in behavioral neurosciences · 2022Review
- Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression.Nature communications · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we examine stress-induced changes in human mPFC glutamate using magnetic resonance spectroscopy (MRS) in two healthy control samples and a third sample of unmedicated participants with MDD who completed the Maastricht acute stress task, and one sample of healthy control participants who completed a no-stress control manipulation. In healthy controls, we find that the magnitude of mPFC glutamate response to the acute stressor decreases as individual levels of perceived stress increase. This adaptative glutamate response is absent in individuals with MDD and is associated with pessimistic expectations during a 1-month follow-up period. Together, this work shows evidence for glutamatergic adaptation to stress that is significantly disrupted in MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.