Evidence map›Paper›PMID 34039638›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic

Sean G Kirk, Parker R Murphy, Xiantao Wang, Charles J Cash, Timothy J Barley, Bridget A Bowman, Abel J Batty, William E Ackerman, Jian Zhang, Leif D Nelin and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Sean G KirkCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
Parker R MurphyCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
Xiantao WangLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD.
Charles J CashCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
Timothy J BarleyCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
Bridget A BowmanCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
Abel J BattyCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
William E AckermanDepartment of Obstetrics and Gynecology, University of Illinois at Chicago College of Medicine, Chicago, IL.
Jian ZhangDepartment of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA; and.ORCID 0000-0002-9523-5296
Leif D NelinCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
Markus HafnerLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD.
Yusen LiuCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH; yusen.liu@nationwidechildrens.org.ORCID 0000-0002-0994-0109
Nationwide Children's Hospital · USNational Institutes of Health · USUniversity of Illinois Chicago · USUniversity of Iowa · US

Funding

Integration of the results from systems-level determination of cis-acting elements into high-resolution maps of posttranscriptional regulatory events.ZIAAR041205 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI HAFNER, MARKUS · 2016 to 2025
$5.5M
The role of AU-rich element binding proteins in shaping target mRNA expressionZIAAR041200 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI HAFNER, MARKUS · 2014 to 2023
$5.1M
Regulation and Function of Mkp-1 During Sepsis.R01AI124029 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2017 to 2021
$1.9M
Role of Protein Ubiquitination in SepsisR01AI121196 · NIAID · UNIVERSITY OF IOWA · PI ZHANG, JIAN · 2016 to 2020
$1.7M
Mkp-1 suppresses immune checkpoint protein PD-L1 to prevent sepsis-associated immune dysfunction and mortalityR21AI142885 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2019 to 2020
$418k
NIAID NIH HHS R01 AI121196NIAID NIH HHS R01 AI124029NIAID NIH HHS R21 AI142885
6 · The paper itself

Abstract

We have previously shown that

Indexed as

AnimalsCells, CulturedDual Specificity Phosphatase 1Escherichia coli InfectionsInterferon-betaMiceMice, Inbred C57BLMice, Knockoutp38 Mitogen-Activated Protein KinasesRAW 264.7 CellsDual Specificity Phosphatase 1Dusp1 protein, mouseInterferon-betap38 Mitogen-Activated Protein Kinases

Identifiers

PMID34039638
PMCPMC8617036
OpenAlexW3193783401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.