ArticleScience advances2021
Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Type 2 diabetes prevention across the life course.Nature medicine · 2026Review
- Endocrinology in maternal-fetal synchronization and developmental origins of susceptibility to metabolic diseases.Endocrine journal · 2026Review
- Environmental influences on seminal plasma: Molecular and functional insights.The Journal of reproduction and development · 2026Review
- Article
- Appropriate Lifelong Circadian Rhythms Are Established During Infancy: A Narrative Review.Clocks & sleep · 2025Review
- Father's adolescent body silhouette is associated with offspring asthma, lung function and BMI through DNA methylation.Communications biology · 2025Article
- A single cell atlas of the mouse seminal vesicle.G3 (Bethesda, Md.) · 2025Article
- Article
- Intergenerational metabolic effects of cold exposure.Nature metabolism · 2025Article
- Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring.Cell metabolism · 2025Article
- The impact of postoperative pain interventions on circadian rhythm disruptions: mechanisms and clinical implications.Frontiers in neuroscience · 2025Review
- Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Maternal circadian rhythm disruption affects neonatal inflammation via metabolic reprograming of myeloid cells.Nature metabolism · 2024Article
- A single cell atlas of the mouse seminal vesicle.bioRxiv : the preprint server for biology · 2024Article
- Paternal impact on the developmental programming of sexual dimorphism.Frontiers in cell and developmental biology · 2024Review
- When Dad's Stress Gets under Kid's Skin-Impacts of Stress on Germline Cargo and Embryonic Development.Biomolecules · 2023Review
- Intergenerational response to sperm competition risk in an invasive mammal.Proceedings. Biological sciences · 2023Article
- The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility.Biomedicines · 2022Review
- The cost of the circadian desynchrony on the Leydig cell function.Scientific reports · 2022Article
- The hidden link between circadian entropy and mental health disorders.Translational psychiatry · 2022Review
Corrections and comments
- Commented on by
Authors and funding
20 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. Less is known about the role of paternal circadian rhythm for offspring health. Here, we disrupted circadian rhythm in male mice by night-restricted feeding and showed that paternal circadian disruption at conception is important for offspring feeding behavior, metabolic health, and oscillatory transcription. Mechanistically, our data suggest that the effect of paternal circadian disruption is not transferred to the offspring via the germ cells but initiated by corticosterone-based parental communication at conception and programmed during in utero development through a state of fetal growth restriction. These findings indicate paternal circadian health at conception as a newly identified determinant of offspring phenotypes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.