Evidence map›Paper›PMID 34039437›Full record

ArticleCancer imaging : the official publication of the International Cancer Imaging Society2021

Primary disease sites and patterns of spread in cases of neurolymphomatosis in the orbit associated with lymphoma.

Seth J Fritzhand, Bita Esmaeli, Jia Sun, J Matthew Debnam

Open access · goldAbstract read
In one paragraph

Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Orbital Neurolymphomatosis in Patient with CNS Lymphoma.Diagnostics (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Article
  7. Neoplastic nerve lesions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Seth J FritzhandSchool of Nursing and Health Studies, Georgetown University, Washington, DC, USA.
Bita EsmaeliOrbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jia SunDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
J Matthew DebnamDepartment of Neuroradiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Blvd., Unit 1482, Houston, TX, 77030, USA. matthew.debnam@mdanderson.org.ORCID http://orcid.org/0000-0002-3095-8936
The University of Texas MD Anderson Cancer Center · USGeorgetown University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
CANCER PREVENTION EDUCAT--STUDENT RESEARCH EXPERIENCESR25CA056452 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shine Chang · 1992 to 2026
$6.9M
NCI NIH HHS NIH/NCI R25CA056452NCI NIH HHS P30 CA016672NCI NIH HHS R25 CA056452NIH HHS NIH/NCI P30 CA016672
6 · The paper itself

Abstract

backgroundNeurolymphomatosis involving the cranial nerves (CNs) is rare. We sought a better understanding of the primary disease sites and patterns of spread in neurolymphomatosis of the orbit and retro-orbital cranial nerves.

methodsPatients with lymphoma and MRI evidence of neurolymphomatosis of CN II, III, IV, V

resultsThe study included 18 patients. The most frequent types of lymphoma were diffuse large B-cell (DLBCL) (n = 9) and marginal zone (n = 3). In 9 patients, lymphoma presented as a mass (n = 7) or infiltrative disease (n = 2) directly involving the orbit; in 6, a maxillofacial mass spread directly to CNs; and in 3, lymphoma at remote sites spread to orbital CNs. Overall, 81 sites of neurolymphomatosis were noted. The most common sites were the maxillary nerve (V

conclusionsBased on our study results, neurolymphomatosis in the orbit appears to be frequently associated with an orbital and/or maxillofacial mass and commonly involves CN V

Indexed as

AdultAgedFemaleHumansMaleMiddle AgedNeurolymphomatosisOrbitRetrospective StudiesYoung AdultCranial nervesLymphomaNeurolymphomatosisOrbits

Identifiers

PMID34039437
PMCPMC8157741
OpenAlexW3164876871

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.