Evidence map›Paper›PMID 34039370›Full record

ArticleJournal of nanobiotechnology2021

Overcoming chemotherapy resistance using pH-sensitive hollow MnO

Zhi-Hang Zhou, Si-Yuan Liang, Tong-Chao Zhao, Xu-Zhuo Chen, Xian-Kun Cao, Ming Qi, Ying-Ying Huang, Wu-Tong Ju, Meng Yang, Dong-Wang Zhu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 55 citations in OpenAlex.

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  6. Innovative nanoparticle strategies for treating oral cancers.Medical oncology (Northwood, London, England) · 2025
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  20. Current trends of targeted therapy for oral squamous cell carcinoma.Journal of cancer research and clinical oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Zhi-Hang Zhou *Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.
Si-Yuan Liang *Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.
Tong-Chao Zhao *Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.
Xu-Zhuo ChenShanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China.
Xian-Kun CaoDepartment of Orthopaedics Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ming QiKey Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University, Shanghai, China.
Ying-Ying HuangDepartment of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.
Wu-Tong JuDepartment of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.
Meng YangDepartment of Clinical Immunology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China.
Dong-Wang ZhuDepartment of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China. zhudw9th@163.com.
Yi-Chuan PangDepartment of Nuclear Medicine, Tenth People's Hospital, Tongji University School of Medicine, No.301 Yanchang Middle Road, Shanghai, 200072, China. pangyichuan@hotmail.com.
Lai-Ping ZhongDepartment of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China. zhonglaiping9th@163.com.
Shanghai Jiao Tong University · CNShanghai Ninth People's Hospital · CNFudan University · CNTongji University · CN

Funding

National Natural Science Foundation of China (CN) 81972525
6 · The paper itself

Abstract

backgroundSmart nanoscale drug delivery systems that target acidic tumor microenvironments (TME) could offer controlled release of drugs and modulate the hypoxic TME to enhance cancer therapy. The majority of previously reported MnO

resultHere, intelligent "theranostic" platforms were synthesized based on hollow mesoporous MnO

conclusionIn conclusion, a remarkable in vivo and in vitro synergistic therapeutic effect is achieved through the combination of TP chemotherapy, which simultaneously triggered a series of antiangiogenic and oxidative antitumor reactions.

Indexed as

Angiogenesis InhibitorsAnimalsAntineoplastic AgentsCarcinoma, Squamous CellCell Line, TumorDrug Delivery SystemsDrug TherapyHead and Neck NeoplasmsHumansHydrogen-Ion ConcentrationHydrogen PeroxideHypoxiaManganese CompoundsMiceMice, Inbred BALB CMice, NudeAngiogenesis InhibitorsAntineoplastic AgentsHydrogen PeroxideManganese CompoundsOxidesAngiogenesisChemotherapyHypoxiaMnO2Oral squamous cell carcinomaTumor microenvironment

Identifiers

PMID34039370
PMCPMC8157461
OpenAlexW3165440170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.