Evidence map›Paper›PMID 34039285›Full record

ArticleBMC cardiovascular disorders2021

Plasma uric acid is related to large arterial stiffness but not to other hemodynamic variables: a study in 606 normotensive and never-medicated hypertensive subjects.

Humam Hamid, Venla Kurra, Manoj Kumar Choudhary, Heidi Bouquin, Onni Niemelä, Mika A P Kähönen, Jukka T Mustonen, Ilkka H Pörsti, Jenni K Koskela

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01742702 (Non-Invasive HaemoDYNAMICs in Primary and Secondary Hypertension), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01742702 unknown statusnot on this map

Non-Invasive HaemoDYNAMICs in Primary and Secondary Hypertension: the DYNAMIC-study

TypeobservationalSponsorTampere UniversityRan2006 to 2025Enrolled2,000ConditionsPrimary Hypertension, Secondary Hypertension, Aortic Stenosis, Renal InsufficiencyArmsNitroglycerin 0.25 mg (single dose, no longer given since January 2017), Salbutamol 400 µg (single dose, no longer given since January 2017), L-arginine (10 min infusion, no longer given since January 2017), Liquorice (2 weeks, glycyrrhizin 290-370 mg daily, no longer given since 2012), Small milk casein-derived polypeptides (12 weeks daily, recordings completed 2011)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Humam Hamid *Faculty of Medicine and Health Technology, Tampere University, FI-33014, Tampere, Finland.
Venla Kurra *Faculty of Medicine and Health Technology, Tampere University, FI-33014, Tampere, Finland.
Manoj Kumar ChoudharyFaculty of Medicine and Health Technology, Tampere University, FI-33014, Tampere, Finland.
Heidi BouquinFaculty of Medicine and Health Technology, Tampere University, FI-33014, Tampere, Finland.
Onni NiemeläFaculty of Medicine and Health Technology, Tampere University, FI-33014, Tampere, Finland.
Mika A P KähönenFaculty of Medicine and Health Technology, Tampere University, FI-33014, Tampere, Finland.
Jukka T MustonenFaculty of Medicine and Health Technology, Tampere University, FI-33014, Tampere, Finland.
Ilkka H PörstiFaculty of Medicine and Health Technology, Tampere University, FI-33014, Tampere, Finland. ilkka.porsti@tuni.fi.
Jenni K KoskelaFaculty of Medicine and Health Technology, Tampere University, FI-33014, Tampere, Finland.
Tampere University · FITampere University Hospital · FISeinäjoki University of Applied Sciences · FITampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElevated level of plasma uric acid (PUA) has been associated with cardiovascular disease, but whether uric acid is an independent risk factor or merely a marker remains controversial.

methodsWe investigated in a cross-sectional setting the association of PUA with hemodynamics in 606 normotensive and never-medicated hypertensive subjects (295 men, 311 women, age range 19-73 years) without cardiovascular disease or gout. In all except 15 individuals, PUA was within the normal range. Supine hemodynamics were recorded using whole-body impedance cardiography and radial tonometric pulse wave analysis.

resultsThe mean concentrations of PUA in age, sex and body mass index adjusted quartiles were 234, 278, 314, and 373 µmol/l, respectively. The highest PUA quartile presented with higher aortic to popliteal pulse wave velocity (PWV) than the lowest quartile (8.7 vs. 8.2 m/s, p = 0.026) in analyses additionally adjusted for plasma concentrations of C-reactive protein, low density lipoprotein cholesterol, triglycerides, and mean aortic blood pressure. No differences in radial and aortic blood pressure, wave reflections, heart rate, cardiac output, and systemic vascular resistance were observed between the quartiles. In linear regression analysis, PUA was an independent explanatory factor for PWV (β = 0.168, p < 0.001, R

conclusionsPUA concentration was independently and directly associated with large arterial stiffness in individuals without cardiovascular disease and PUA levels predominantly within the normal range. Trial registration ClinicalTrials.gov NCT01742702.

Indexed as

Blood PressureVascular StiffnessAdultAgedBiomarkersCardiography, ImpedanceCase-Control StudiesCross-Sectional StudiesFemaleHumansHypertensionMaleMiddle AgedPulse Wave AnalysisUric AcidYoung AdultBiomarkersUric AcidArterial stiffnessHemodynamicsImpedance cardiographyPulse wave analysisUric acid

Identifiers

PMID34039285
PMCPMC8152327
OpenAlexW3165196390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.