Evidence map›Paper›PMID 34039240›Full record

ArticleRNA biology2021

Comprehensive characterization of mRNAs associated with yeast cytosolic aminoacyl-tRNA synthetases.

Shahar Garin, Ofri Levi, Megan E Forrest, Anthony Antonellis, Yoav S Arava

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. A missense, loss-of-functionCold Spring Harbor molecular case studies · 2022
    Article
  4. Article
  5. Article
  6. Genes · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shahar GarinFaculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Ofri LeviFaculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Megan E ForrestDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
Anthony AntonellisDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
Yoav S AravaFaculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Technion – Israel Institute of Technology · ILUniversity of Michigan–Ann Arbor · US

Funding

Defining the Role of Aminoacyl-tRNA Synthetases in Human Health and DiseaseR35GM136441 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Anthony Antonellis · 2020 to 2026
$2.8M
NIGMS NIH HHS R35 GM136441
6 · The paper itself

Abstract

Aminoacyl-tRNA synthetases (aaRSs) are a conserved family of enzymes with an essential role in protein synthesis: ligating amino acids to cognate tRNA molecules for translation. In addition to their role in tRNA charging, aaRSs have acquired non-canonical functions, including post-transcriptional regulation of mRNA expression. Yet, the extent and mechanisms of these post-transcriptional functions are largely unknown. Herein, we performed a comprehensive transcriptome analysis to define the mRNAs that are associated with almost all aaRSs present in

Indexed as

Gene Expression Regulation, FungalAmino Acyl-tRNA SynthetasesCytosolRNA, MessengerRNA, TransferSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAmino Acyl-tRNA SynthetasesRNA, MessengerRNA, TransferSaccharomyces cerevisiae ProteinsAminoacyl tRNA synthetasesmRNApost-transcriptional regulationRIP-seqRNA-binding proteinsyeast

Identifiers

PMID34039240
PMCPMC8632134
OpenAlexW3164255311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.