ArticleThe American journal of clinical nutrition2021
Diet and erythrocyte metal concentrations in early pregnancy-cross-sectional analysis in Project Viva.
Article in The American journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exposure to heavy metals in utero and autism spectrum disorder at age 3: a meta-analysis of two longitudinal cohorts of siblings of children with autism.Environmental health : a global access science source · 2024Pooled it
- Associations of prenatal metal exposures with autism-related outcomes in the ECHO cohort.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- The (ab)use of food frequency questionnaire data in substitution modelling in nutritional epidemiology: a critique.European journal of clinical nutrition · 2026Review
- Associations of Metal Mixtures During Early Pregnancy With Midlife Obesity and Body Composition: A Prospective Study.Obesity (Silver Spring, Md.) · 2025Article
- Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Prenatal metal exposures and kidney function in adolescence in Project Viva.Environmental health : a global access science source · 2024Article
- Prenatal blood metals, per- and polyfluoroalkyl substances and antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion.Environmental research · 2024Article
- First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort.Environment international · 2024Article
- Cross-sectional and prospective associations of early childhood circulating metals with early and mid-childhood cognition in the Project Viva cohort.Environmental research · 2024Article
- Recent Insights and Recommendations for Preventing Excessive Gestational Weight Gain.Journal of clinical medicine · 2024Review
- Association between Mediterranean diet and metal mixtures concentrations in pregnant people from the New Hampshire Birth Cohort Study.The Science of the total environment · 2024Article
- Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review.Frontiers in public health · 2024Review
- Associations Between Prenatal Blood Metals and Vitamins and Cord Blood Peptide Hormone Concentrations.Global reproductive health · 2023Article
- Correlates of whole blood metal concentrations among reproductive-aged Black women.Journal of exposure science & environmental epidemiology · 2023Article
- Epidemiologic Advances Generated by the Human Health Exposure Analysis Resource Program.Current epidemiology reports · 2023Article
- Mixtures of Metals and Micronutrients in Early Pregnancy and Cognition in Early and Mid-Childhood: Findings from the Project Viva Cohort.Environmental health perspectives · 2023Article
- Early pregnancy essential and non-essential metal mixtures and maternal antepartum and postpartum depressive symptoms.Neurotoxicology · 2023Article
- Non-essential and essential trace element mixtures and kidney function in early pregnancy - A cross-sectional analysis in project viva.Environmental research · 2023Article
- Longitudinal trajectories and determinants of plasma per- and polyfluoroalkyl substance (PFAS) levels from birth to early childhood and metabolomic associations: A pilot study in the Boston Birth Cohort.Precision nutrition · 2022Article
- Association between prenatal metal exposure and adverse respiratory symptoms in childhood.Environmental research · 2022Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
backgroundDietary sources of metals are not well established among pregnant women in the United States.
objectiveWe aimed to perform a diet-wide association study (DWAS) of metals during the first trimester of pregnancy.
methodsIn early pregnancy (11.3 ± 2.8 weeks of gestation), 1196 women from Project Viva (recruited 1999-2002 in eastern Massachusetts) completed a validated FFQ (135 food items) and underwent measurements of erythrocyte metals [arsenic (As), barium, cadmium, cesium (Cs), copper, mercury (Hg), magnesium, manganese, lead (Pb), selenium (Se), zinc]. The DWAS involved a systematic evaluation and visualization of all bivariate relations for each food-metal combination. For dietary items with strong associations with erythrocyte metals, we applied targeted maximum likelihood estimations and substitution models to evaluate how hypothetical dietary interventions would influence metals' concentrations.
resultsParticipants' mean ± SD age was 32.5 ± 4.5 y and prepregnancy BMI was 24.8 ± 5.4 kg/m2; they were mostly white (75.9%), college graduates (72.4%), married or cohabitating (94.6%), had a household income >$70,000/y (63.5%), and had never smoked (67.1%). Compared with other US-based cohorts, the overall diet quality of participants was above average, and concentrations of erythrocyte metals were lower. The DWAS identified significant associations of several food items with As, Hg, Pb, Cs, and Se; for example, As was higher for each SD increment in fresh fruit (11.5%; 95% CI: 4.9%, 18.4%), white rice (17.9%; 95% CI: 9.4%, 26.9%), and seafood (50.9%; 95% CI: 42.8%, 59.3%). Following the guidelines for pregnant women to consume ≤3 servings/wk of seafood was associated with lower As (-0.55 ng/g; 95% CI: -0.82, -0.28 ng/g) and lower Hg (-2.67 ng/g; 95% CI: -3.55, -1.80 ng/g). Substituting white rice with bread, pasta, tortilla, and potato was also associated with lower As (35%-50%) and Hg (35%-70%).
conclusionsOur DWAS provides a systematic evaluation of diet-metals relations. Prenatal diet may be an important source of exposures to metals.
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