Evidence map›Paper›PMID 34038547›Full record

ReviewJapanese journal of clinical oncology2021

Current status of medical treatment for gastroenteropancreatic neuroendocrine neoplasms and future perspectives.

Susumu Hijioka, Chigusa Morizane, Masafumi Ikeda, Hiroshi Ishii, Takuji Okusaka, Junji Furuse

Open access · hybridAbstract readReview
In one paragraph

Review in Japanese journal of clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Susumu HijiokaDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Chigusa MorizaneDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Masafumi IkedaDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Hiroshi IshiiDepartment of Gastroenterology, Chiba Cancer Center, Chiba, Japan.
Takuji OkusakaDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Junji FuruseDepartment of Medical Oncology, Kyorin University Faculty of Medicine, Tokyo, Japan.
Chiba Cancer Center · JPKyorin University · JPNational Cancer Center Hospital East · JP

Funding

Japan Pancreas SocietyNational Cancer Center
6 · The paper itself

Abstract

Neuroendocrine neoplasms (NENs) constitute a heterogeneous group of tumors. In this review, we summarize the results of various clinical trials that have been conducted to investigate the efficacy and safety of various therapeutic options for NENs. Based on the encouraging results obtained from these trials, various therapeutic options have been established for the treatment of NENs, including somatostatin analogs (SSAs), molecularly targeted drugs and cytotoxic agents. In addition, peptide receptor radionucleotide therapy has recently been evaluated for the treatment of various NENs. We also discuss the approach for selecting the appropriate drugs and sequence of treatment with the various drug classes, as recommended by different treatment guidelines. Finally, we discuss the scope for future research in this field, especially into the merits of combination therapy with molecularly targeted drugs plus SSAs, along with ongoing studies.

Indexed as

Gastrointestinal NeoplasmsNeuroendocrine TumorsPancreatic NeoplasmsCombined Modality TherapyHumansIntestinal NeoplasmsSomatostatinStomach NeoplasmsSomatostatincytotoxic agentgastroenteropancreatic neuroendocrine neoplasmsmolecular-targeted agentPancreatic neuroendocrine tumorssomatostatin analogtreatment strategy

Identifiers

PMID34038547
PMCPMC8326384
OpenAlexW3165681459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.