ArticleAge and ageing2021
The rate by which mortality increase with age is the same for those who experienced chronic disease as for the general population.
Article in Age and ageing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Heart failure with preserved ejection fraction shows no excess mortality in older patients: a population-matched relative survival analysis.GeroScience · 2026Observational
- Global under- and overprescribing of drugs-a scoping review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
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- Suprapubic catheter insertion: a multicentre review on mortality during short-, medium- and long-term follow-up.Annals of the Royal College of Surgeons of England · 2026Article
- Aging Rewires Neuronal Metabolism, Exacerbating Cell Death After Ischemic Stroke: A Hidden Reason for the Failure of Neuroprotection.International journal of molecular sciences · 2025Article
- Oral and Oropharyngeal Cancer Mortality in Brazil: Estimates and Projections up to 2042.Community dentistry and oral epidemiology · 2025Article
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- The impact of knowledge of hospitalization on mortality predictions.Health services & outcomes research methodology · 2025Article
- Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors.GeroScience · 2025Article
- Article
- Distinguishing the intrinsic and extrinsic causes of changes in human mortality by examining life-table aging rate (LAR) trajectories through the lens of generalized Gompertz-Makeham law.Biogerontology · 2025Article
- The relationship between serum uric acid and accelerated aging in middle-aged and older adults: a prospective cohort study based on CHARLS.The journal of nutrition, health & aging · 2025Article
- Surgical vs. non-surgical management of cervical spine fractures associated with ankylosing spinal disorders: a matched retrospective comparison assessing mortality.BMC musculoskeletal disorders · 2025Article
- Mortality of type 2 diabetes in Germany: additional insights from Gompertz models.Acta diabetologica · 2024Article
- Exploring the determinants associated with adult mortality in Malta: A cohort study between 2014 and 2020.Public health in practice (Oxford, England) · 2024Article
- Trajectories of Body Mass Index and Risk for Diabetes Complications and All-Cause Mortality in Finnish Type 2 Diabetes Patients.Clinical epidemiology · 2024Article
- Frailty Among Breast Cancer Survivors: Evidence From Swedish Population Data.American journal of epidemiology · 2023Article
- Factors predicting death and cancer in patients with giant cell arteritis in Western Norway 1972-2012: a retrospective observational cohort study.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMortality doubles approximately every 6-7 years during adulthood. This exponential increase in death risk with chronological age is the population-level manifestation of ageing, and often referred to as the rate-of-ageing.
objectiveWe explore whether the onset of severe chronic disease alters the rate-of-ageing.
methodsUsing Swedish register data covering the entire population of the birth cohorts 1927-30, we analyse whether being diagnosed with myocardial infarction, diabetes or cancer results in a deviation of the rate-of-ageing from those of the total population. We also quantify the long-term mortality effects of these diseases, using ages with equivalent mortality levels for those with disease and the total population.
resultsNone of the diseases revealed a sustained effect on the rate-of-ageing. After an initial switch upwards in the level of mortality, the rate-of-ageing returned to the same pace as for the total population. The time it takes for the rate to return depends on the disease. The long-term effects of diabetes and myocardial infarction amount to mortality levels that are equivalent to those aged 5-7 years older in the total population. For cancer, the level of mortality returns to that of the total population.
conclusionOur results suggest an underlying process of ageing that causes mortality to increase at a set pace, with every year older we become. This process is not affected by disease history. The persistence of the rate-of-ageing motivates a critical discussion of what role disease prevention can play in altering the progression of ageing.
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