SynthesisPloS one2021
Effectiveness of powered exoskeleton use on gait in individuals with cerebral palsy: A systematic review.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Satisfaction analysis of overground gait exoskeletons in people with neurological pathology. a systematic review.Journal of neuroengineering and rehabilitation · 2023Pooled it
- Use of Robot-Assisted Gait Training in Pediatric Patients with Cerebral Palsy in an Inpatient Setting-A Randomized Controlled Trial.Sensors (Basel, Switzerland) · 2022Trial
- Effects of ATLAS 2030 gait exoskeleton on strength and range of motion in children with spinal muscular atrophy II: a case series.Journal of neuroengineering and rehabilitation · 2022Trial
- Exoskeleton-assisted physiotherapy in school and outpatient contexts for minimally ambulant children with cerebral palsy.Developmental medicine and child neurology · 2026Article
- Lower limb active exoskeletons, exosuits, assistive devices and specifications: a scoping review.Journal of neuroengineering and rehabilitation · 2026Article
- Body-weight support is the primary driver of elevated walking cost in cerebral palsy.Research square · 2026Article
- Gait Event Detection From Thigh Segment Kinematics in Children With Crouch Gait.IEEE journal of translational engineering in health and medicine · 2026Article
- Evaluating the rehabilitative and assistive impact of the Agilik exoskeleton: a pre-post single-group study in children with cerebral palsy.Frontiers in medicine · 2026Article
- Therapeutic Benefits of Robotics and Exoskeletons for Gait and Postural Balance Among Children and Adolescents with Cerebral Palsy: An Overview of Systematic Reviews.Healthcare (Basel, Switzerland) · 2025Review
- Biomechanical models in the lower-limb exoskeletons development: a review.Journal of neuroengineering and rehabilitation · 2025Review
- Exoskeleton therapy in cerebral palsy: improved gait endurance without kinematic change.Frontiers in human neuroscience · 2025Article
- Effects of robot rehabilitation on the motor function and gait in children with cerebral palsy: a systematic review and meta-analysis.Journal of exercise rehabilitation · 2024Review
- A position statement on the post gene-therapy rehabilitation of aromatic I-amino acid decarboxylase deficiency patients.Orphanet journal of rare diseases · 2024Article
- Benefits of robotic gait assistance with ATLAS 2030 in children with cerebral palsy.Frontiers in pediatrics · 2024Article
- Artificial intelligence and machine learning approaches in cerebral palsy diagnosis, prognosis, and management: a comprehensive review.PeerJ. Computer science · 2024Review
- Effect of Gait Speed on Trajectory Prediction Using Deep Learning Models for Exoskeleton Applications.Sensors (Basel, Switzerland) · 2023Article
- Robot-Assisted Gait Training with Trexo Home: Users, Usage and Initial Impacts.Children (Basel, Switzerland) · 2023Article
- Safety and Feasibility of Robot-assisted Gait Training in Adults with Cerebral Palsy in an Inpatient Setting - an Observational Study.Journal of developmental and physical disabilities · 2023Article
- A low-power ankle-foot prosthesis for push-off enhancement.Wearable technologies · 2023Article
- Interleaved Assistance and Resistance for Exoskeleton Mediated Gait Training: Validation, Feasibility and Effects.Proceedings of the ... IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics. IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral palsy (CP) is a leading cause of childhood disability. The motor impairments of individuals with CP significantly affect the kinematics of an efficient gait pattern. Robotic therapies have become increasingly popular as an intervention to address this. Powered lower limb exoskeletons (PoLLE) are a novel form of robotic therapy that allow the individual to perform over-ground gait training and yet its effectiveness for CP is unknown. PURPOSE: To determine the effectiveness of PoLLE use on gait in individuals with CP.
methodA systematic search of eight electronic databases was conducted in March 2020. Studies included children (0-18 years) and or adults (18+ years) diagnosed with CP who used a PoLLE for gait training. This review was conducted and reported in line with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement, with the methodology registered with PROSPERO (CRD42020177160). A modified version of the McMaster critical review form for quantitative studies was used to assess the methodological quality. Due to the heterogeneity of the included studies, a descriptive synthesis using the National Health & Medical Research Council (NHMRC) FORM framework was undertaken.
resultsOf the 2089 studies screened, ten case series and three case studies met the inclusion criteria highlighting the current evidence base is emerging and low level. A range of PoLLEs were investigated with effectiveness measured by using a number of outcome measures. Collectively, the body of evidence indicates there is some consistent positive evidence on the effectiveness of PoLLE in improving gait in individuals with CP, with minimal adverse effects. While this is a positive and encouraging finding for an emerging technology, methodological concerns also need to be acknowledged.
conclusionWith rapidly evolving technology, PoLLEs could play a transformative role in the lives of people impacted by CP. Ongoing research is required to further strengthen the evidence base and address current methodological concerns.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.