ArticleAging cell2021
Genetic associations for two biological age measures point to distinct aging phenotypes.
Article in Aging cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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Who cites it
102 citing papers in PubMed.
- Accelerated aging as a key mechanism linking diet quality to cardiovascular disease: a prospective mediation analysis in the UK Biobank.GeroScience · 2026Article
- Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables.Nature communications · 2026Article
- The impact of cumulative obesity and genetic susceptibility on biological aging in Chinese older adults.GeroScience · 2026Article
- Additional considerations on PhenoAge construction in the association between proteinuria and biological aging.International urology and nephrology · 2026Article
- Genetically proxied glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor pathway modulation is associated with favorable aging phenotypes: a drug-target Mendelian randomization study.Cardiovascular diabetology · 2026Article
- Biological age acceleration and bradyarrhythmia: evidence from clinical and epigenetic perspectives.Clinical epigenetics · 2026Article
- Association between 24-h proteinuria and phenotypic age acceleration in adults with preserved kidney function: a cross-sectional study.International urology and nephrology · 2026Article
- Unraveling 'F' factor: towards a genetic-clinical framework for the musculoskeletal-heart crosstalk in metabolic aging.Cardiovascular diabetology · 2026Article
- Impact of body roundness index on cognitive decline and cognitive impairment in middle-aged and older adults ≥ 45 years: mediating role of biological aging.Scientific reports · 2026Article
- Associations between phenotypic age and carotid atherosclerosis among the general population: evidence from a multi-stage study.BMC cardiovascular disorders · 2026Article
- Genetic insights into socioeconomic inequalities and adiposity-related interventions for reducing accelerated biological aging.International journal of obesity (2005) · 2026Observational
- The impact of triglyceride-glucose-related obesity indices and sleep patterns on accelerated aging: evidence from NHANES 2005-2018.Hormones (Athens, Greece) · 2026Article
- Phenotypic age acceleration and early-onset lung cancer: a case-control and prognostic cohort study involving multiple clinical centres with validation in the UK Biobank.EBioMedicine · 2026Article
- Biological age acceleration and interaction with genetic predisposition in the risk of type 2 diabetes and coronary artery disease.GeroScience · 2026Article
- Association between biological aging and coronary heart disease: A secondary analysis of two observational studies.iScience · 2026Article
- Biological aging, a mediator between smoking and chronic obstructive pulmonary disease: evidence from a hospital-based cohort study in China.BMC pulmonary medicine · 2026Article
- Biological ageing, diet quality, and stroke: evidence from two population-based studies and an exploratory hospital-based Chinese cross-sectional dataset.Frontiers in nutrition · 2026Article
- Modifiable lifestyle factors and 4.9-Year changes in phenotypic age in the Taiwan biobank.Frontiers in aging · 2026Article
- Personality traits and biological aging: the mediating role of coping behavior.Frontiers in psychology · 2026Article
- Facial skin aging is a potential osteoporosis-associated marker: evidence from both observational and genetic studies.Journal of bone and mineral metabolism · 2026Article
42 more citing papers are in PubMed but not listed here.
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Abstract
Biological age measures outperform chronological age in predicting various aging outcomes, yet little is known regarding genetic predisposition. We performed genome-wide association scans of two age-adjusted biological age measures (PhenoAgeAcceleration and BioAgeAcceleration), estimated from clinical biochemistry markers (Levine et al., 2018; Levine, 2013) in European-descent participants from UK Biobank. The strongest signals were found in the APOE gene, tagged by the two major protein-coding SNPs, PhenoAgeAccel-rs429358 (APOE e4 determinant) (p = 1.50 × 10
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