Evidence map›Paper›PMID 34037972›Full record

ArticleCardiovascular toxicology2021

Phloretin Alleviates Arsenic Trioxide-Induced Apoptosis of H9c2 Cardiomyoblasts via Downregulation in Ca

Vineetha Vadavanath Prabhakaran, Raghu Kozhiparambil Gopalan

Abstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. The role of wnt signaling in diabetes-induced osteoporosis.Diabetology & metabolic syndrome · 2023
    Review
  3. Review
  4. Allosteric links between the hydrophilic N-terminus and transmembrane core of human NaProtein science : a publication of the Protein Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vineetha Vadavanath PrabhakaranAgroprocessing and Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR - NIIST), Thiruvananthapuram, Kerala, 695019, India.
Raghu Kozhiparambil GopalanAgroprocessing and Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR - NIIST), Thiruvananthapuram, Kerala, 695019, India. raghukgopal2009@gmail.com.
National Institute for Interdisciplinary Science and Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs for treating acute promyelocytic leukemia patients, but its clinical use is hampered due to cardiotoxicity. The present investigation unveils the mechanism underlying ATO-induced oxidative stress that promotes calcineurin (a ubiquitous Ca

Indexed as

AnimalsAnti-Inflammatory AgentsApoptosisApoptosis Regulatory ProteinsArsenic TrioxideCalcineurinCalciumCalcium SignalingCytokinesHumansInflammation MediatorsMCF-7 CellsMyoblasts, CardiacNFATC Transcription FactorsPhloretinRatsAnti-Inflammatory AgentsApoptosis Regulatory ProteinsArsenic TrioxideCalcineurinCalciumCytokinesInflammation MediatorsNFATC Transcription FactorsPhloretinApoptosisArsenic trioxideCalcineurinH9c2 cellsInflammatory cytokinesPhloretin

Identifiers

PMID34037972
OpenAlexW3164764763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.