Evidence map›Paper›PMID 34037961›Full record

ArticleEndocrine2021

Antiphospholipid antibodies in patients with Graves' orbitopathy: preliminary data.

Mirjana B Bećarević, Marija Sarić Matutinović, Miloš Žarković, Biljana Nedeljković Beleslin, Jasmina Ćirić, Svetlana D Ignjatović

Abstract read
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In one paragraph

Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mirjana B BećarevićUniversity of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia. mirjana.becarevic@mf.uns.ac.rs.ORCID 0000-0003-2114-8621
Marija Sarić MatutinovićUniversity of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia.
Miloš ŽarkovićUniversity of Belgrade, School of Medicine, Belgrade, Serbia and Clinic of Endocrinology, diabetes and metabolic diseases, Clinical Centre of Serbia, Belgrade, Serbia.
Biljana Nedeljković BeleslinUniversity of Belgrade, School of Medicine, Belgrade, Serbia and Clinic of Endocrinology, diabetes and metabolic diseases, Clinical Centre of Serbia, Belgrade, Serbia.
Jasmina ĆirićUniversity of Belgrade, School of Medicine, Belgrade, Serbia and Clinic of Endocrinology, diabetes and metabolic diseases, Clinical Centre of Serbia, Belgrade, Serbia.
Svetlana D IgnjatovićUniversity of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia.
University of Belgrade · RSUniversity of Novi Sad · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGraves' orbitopathy (GO) is an inflammatory autoimmune disorder of the orbit and while the antiphospholipid antibodies (aPL) Abs were associated with the markers of inflammation in the antiphospholipid syndrome (APS), there is no literature that investigate the presence of aPL Abs in GO. We analyzed the prevalence of aPL Abs and the differences between aPL (+) and aPL (-) subgroups of GO patients.

methodsStudy included consecutive patients with GO (66 with Graves' (GD), 10 with Hashimoto (HD), and 8 were euthyroid). Anticardiolipin (aCL) and anti-beta 2glycoprotein I (aβ2gpI) Abs were measured by ELISA.

resultsaPL Abs were present in 9/84 (10.71%) patients. The IgM aβ2gpI Abs were present in 8/66 and in 1/10 patients with GD and HD. The IgG aCL Abs were present in one GD patient, and IgM aCL were present in 3/66 GD and in 1/10 patients with HD. In GD group, anti-Tg Abs were in positive correlation with aβ2gpI IgG (p = 0.000) and with anti-TPO Abs (p = 0.016). In HD group, anti-Tg Abs were in positive correlation with IgM aCL (p = 0.042), while anti-TPO Abs were in positive correlation with aβ2gpI IgM (p = 0.014).

conclusionThis study is the first report of the aPL Abs presence in GO patients. The anti-thyroid Abs were linked to aPL suggesting that their presence is not the sole consequence of hyperstimulation of autoreactive B-lymphocytes. Larger studies are necessary to confirm potential cause-effect relations.

Indexed as

Graves OphthalmopathyAntibodies, AnticardiolipinAntibodies, Antiphospholipidbeta 2-Glycoprotein IHumansPreliminary DataAntibodies, AnticardiolipinAntibodies, Antiphospholipidbeta 2-Glycoprotein IAntiphospholipid antibodiesApolipoproteinsAutoimmune thyroid diseasesGraves’ orbitopathyInterleukine 6

Identifiers

PMID34037961
OpenAlexW3165839440

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.