Evidence map›Paper›PMID 34037896›Full record

ArticleEJNMMI radiopharmacy and chemistry2021

Optimised GMP-compliant production of [

Klaudia A Cybulska, Vera Bloemers, Lars R Perk, Peter Laverman

Open access · goldAbstract read
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Journal of neurology · 2024
    Trial
  2. Article
  3. Article
  4. Article
  5. Journal of neurology · 2026
    Article
  6. Comparison ofEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  7. Increased [Biomolecules · 2025
    Article
  8. Fully Automated Production of (((Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  9. Production of [EJNMMI radiopharmacy and chemistry · 2024
    Article
  10. GMP-compliant automated radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2024
    Article
  11. Automated radiosynthesis of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2024
    Article
  12. Translating a radiolabeled imaging agent to the clinic.Advanced drug delivery reviews · 2022
    Review
  13. An automated radiosynthesis of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Klaudia A CybulskaRadboud Translational Medicine B.V., Geert Grooteplein 21, Nijmegen, 6525 EZ, Netherlands. klaudia.cybulska@radboudumc.nl.ORCID http://orcid.org/0000-0003-3530-2845
Vera BloemersRadboud Translational Medicine B.V., Geert Grooteplein 21, Nijmegen, 6525 EZ, Netherlands.
Lars R PerkRadboud Translational Medicine B.V., Geert Grooteplein 21, Nijmegen, 6525 EZ, Netherlands.
Peter LavermanDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein 10, Nijmegen, 6525 GA, Netherlands.
Radboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe translocator protein 18 kDa is recognised as an important biomarker for neuroinflammation due to its soaring expression in microglia. This process is common for various neurological disorders. DPA-714 is a potent TSPO-specific ligand which found its use in Positron Emission Tomography following substitution of fluorine-19 with fluorine-18, a positron-emitting radionuclide. [

results[

conclusionTo the best of our knowledge, the process presented herein is the most efficient [

Indexed as

[18F]DPA-714Fluorine-18GMPNeuroinflammationPBRPETRadiochemistryRadiopharmacyTrasis AllinOneTSPO

Identifiers

PMID34037896
PMCPMC8155128
OpenAlexW3164533373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.