ArticleInsights into imaging2021
Significance of intra-nodular vessel sign in differentiating benign and malignant pulmonary ground-glass nodules.
Article in Insights into imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Combined Model Integrating Clinical-Imaging and Deep Learning to Discriminate Between Persistent Inflammatory and Malignant Subsolid Pulmonary Nodules.Journal of imaging informatics in medicine · 2026Article
- Semantic CT features and differentiation model: new primary lung cancer versus metastasis after previous malignancy.European radiology · 2026Article
- A CT-based multi-scale fusion model with SHAP interpretation for preoperative differentiation between lung adenocarcinoma in situ/minimally invasive adenocarcinoma and invasive adenocarcinoma: a multicenter study.Frontiers in oncology · 2026Article
- CT prediction of malignancy in part-solid pulmonary nodules based on vascular interruption and distortion.Frontiers in medicine · 2026Article
- CT combined with 3D-CTBA to analyze the vasculature around pulmonary ground glass nodules and its value in diagnosis.Journal of cardiothoracic surgery · 2025Article
- Lesion-vessel spatial relationship: a significant indicator for differentiation and evaluation of pulmonary ground-glass nodules.Quantitative imaging in medicine and surgery · 2025Article
- Photon-counting detector CT provides superior subsolid nodule characterization compared to same-day energy-integrating detector CT.European radiology · 2025Article
- Monoexponential, biexponential, stretched exponential and diffusion kurtosis models of diffusion-weighted imaging: a quantitative differentiation of solitary pulmonary lesion.BMC medical imaging · 2024Article
- Progressive changes in non-neoplastic ground-glass nodules on follow-up computed tomography (CT).Quantitative imaging in medicine and surgery · 2024Article
- Establishing and validation of the VBV score for assessing Lung ground-glass nodules based on high-resolution computed tomography.Journal of cardiothoracic surgery · 2024Article
- Tumor blood vessel in 3D reconstruction CT imaging as an risk indicator for growth of pulmonary nodule with ground-glass opacity.Journal of cardiothoracic surgery · 2023Article
- Differentiation of pulmonary solid nodules attached to the pleura detected by thin-section CT.Insights into imaging · 2023Article
- Quantitative evaluation of density variability in the lesion-lung boundary zone to differentiate pulmonary subsolid nodules.Quantitative imaging in medicine and surgery · 2023Article
- Correlations Between Inflammatory Cell Infiltration and Relative Density and the Boundary Manifestation of Pulmonary Non-Neoplastic Ground Glass Nodules.Journal of inflammation research · 2023Article
- Potential Role of Intrapulmonary Concomitant Lesions in Differentiating Non-Neoplastic and Neoplastic Ground Glass Nodules.Journal of inflammation research · 2023Article
- A novel nomogram model combining CT texture features and urine energy metabolism to differentiate single benign from malignant pulmonary nodule.Frontiers in oncology · 2022Article
- Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative Study.Infection and drug resistance · 2022Article
- Differential Diagnosis of Nonabsorbable Inflammatory and Malignant Subsolid Nodules with a Solid Component ≤5 mm.Journal of inflammation research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe presence of pulmonary vessels inside ground-glass nodules (GGNs) of different nature is a very common occurrence. This study aimed to reveal the significance of pulmonary vessels displayed in GGNs in their diagnosis and differential diagnosis.
resultsA total of 149 malignant and 130 benign GGNs confirmed by postoperative pathological examination were retrospectively enrolled in this study. There were significant differences in size, shape, nodule-lung interface, pleural traction, lobulation, and spiculation (each p < 0.05) between benign and malignant GGNs. Compared with benign GGNs, intra-nodular vessels were more common in malignant GGNs (67.79% vs. 54.62%, p = 0.024), while the vascular categories were similar (p = 0.663). After adjusting the nodule size and the distance between the nodule center and adjacent pleura [radius-distance ratio, RDR], the occurrences of internal vessels between them were similar. The number of intra-nodular vessels was positively correlated with nodular diameter and RDR. Vascular changes were more common in malignant than benign GGNs (52.48% vs. 18.31%, p < 0.0001), which mainly manifested as distortion and/or dilation of pulmonary veins (61.19%). The occurrence rate, number, and changes of internal vessels had no significant differences among all the pre-invasive and invasive lesions (each p > 0.05).
conclusionsThe incidence of internal vessels in GGNs is mainly related to their size and the distance between nodule and pleura rather than the pathological nature. However, GGNs with dilated or distorted internal vessels, especially pulmonary veins, have a higher possibility of malignancy.
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