ArticleMolecular biology and evolution2021
Broad Concordance in the Spatial Distribution of Adaptive and Neutral Genetic Variation across an Elevational Gradient in Deer Mice.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Genomic-Environmental Integration Predicts Climate Vulnerability and Adaptive Potential of Tibetan Plateau Herpetofauna.Integrative zoology · 2026Article
- Adaptation across an extreme elevational gradient in Andean leaf-eared mice, the world's highest-dwelling mammal.Science (New York, N.Y.) · 2026Article
- The Genetic and Morphological Basis of Local Adaptation to Elevational Extremes in an Alpine Finch.Ecology and evolution · 2026Article
- Museum genomics suggests long-term population decline in a putatively extinct bumble bee.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- High-elevation adaptation and gestational hypoxia jointly shape vascular development in a rodent placenta.The Journal of physiology · 2025Article
- Population genomics provides new insights into the genetic variation patterns, population demographic history, and high-altitude adaptation of Sophora moorcroftiana.BMC plant biology · 2025Article
- Geographic Variation in Epigenetic Responses to Hypoxia in Deer Mice (Peromyscus maniculatus) Distributed Along an Elevational Gradient.Molecular ecology · 2025Article
- Next-generation data filtering in the genomics era.Nature reviews. Genetics · 2024Review
- To what extent do physiological tolerances determine elevational range limits of mammals?The Journal of physiology · 2024Article
- Selection and Gene Duplication Associated With High-Elevation Diversification in Pristimantis, the Largest Terrestrial Vertebrate Genus.Genome biology and evolution · 2024Article
- Putative climate adaptation in American pikas (Ochotona princeps) is associated with copy number variation across environmental gradients.Scientific reports · 2024Article
- Evolved changes in phenotype across skeletal muscles in deer mice native to high altitude.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors.Nature ecology & evolution · 2024Article
- Local adaptation and future climate vulnerability in a wild rodent.Nature communications · 2023Article
- Genomic insights into the mystery of mouse mummies on the summits of Atacama volcanoes.Current biology : CB · 2023Article
- Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice.Molecular ecology · 2023Article
- Adaptive structural and functional evolution of the placenta protects fetal growth in high-elevation deer mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comparative genomics reveals putative evidence for high-elevation adaptation in the American pika (Ochotona princeps).G3 (Bethesda, Md.) · 2022Review
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7 authors.
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Abstract
When species are continuously distributed across environmental gradients, the relative strength of selection and gene flow shape spatial patterns of genetic variation, potentially leading to variable levels of differentiation across loci. Determining whether adaptive genetic variation tends to be structured differently than neutral variation along environmental gradients is an open and important question in evolutionary genetics. We performed exome-wide population genomic analysis on deer mice sampled along an elevational gradient of nearly 4,000 m of vertical relief. Using a combination of selection scans, genotype-environment associations, and geographic cline analyses, we found that a large proportion of the exome has experienced a history of altitude-related selection. Elevational clines for nearly 30% of these putatively adaptive loci were shifted significantly up- or downslope of clines for loci that did not bear similar signatures of selection. Many of these selection targets can be plausibly linked to known phenotypic differences between highland and lowland deer mice, although the vast majority of these candidates have not been reported in other studies of highland taxa. Together, these results suggest new hypotheses about the genetic basis of physiological adaptation to high altitude, and the spatial distribution of adaptive genetic variation along environmental gradients.
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