Evidence map›Paper›PMID 34037753›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial.

Ahmed M Arzika, Ramatou Maliki, Amza Abdou, Alio K Mankara, Abdoul N Harouna, Catherine Cook, Armin Hinterwirth, Lee Worden, Lina Zhong, Cindi Chen and 11 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02047981 (Evaluating Impact of Azithromycin Mass Drug Administrations on All-cause Mortality and Antibiotic Resistance), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02047981 phase4completednot on this map

Evaluating Impact of Azithromycin Mass Drug Administrations on All-cause Mortality and Antibiotic Resistance: Mortality Trial

TypeinterventionalSponsorUniversity of California, San FranciscoRan2014 to 2018Enrolled190,238ConditionsChildhood MortalityArmsAzithromycin, Placebo
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  11. Review
  12. Article
  13. Antibiotic perturbations to the gut microbiome.Nature reviews. Microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ahmed M ArzikaThe Carter Center, Niamey, Niger.
Ramatou MalikiThe Carter Center, Niamey, Niger.
Amza AbdouMinistry of Health, Niamey, Niger.
Alio K MankaraThe Carter Center, Niamey, Niger.
Abdoul N HarounaThe Carter Center, Niamey, Niger.
Catherine CookFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Armin HinterwirthFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Lee WordenFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Lina ZhongFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Cindi ChenFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Kevin RuderFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Zhaoxia ZhouFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Elodie LebasFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Kieran S O'BrienFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Catherine E OldenburgFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Victoria LeFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Benjamin F ArnoldFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Travis C PorcoFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Jeremy D KeenanFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Thomas M LietmanFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.
Thuy DoanFrancis I Proctor Foundation, Universit of California San Francisco, San Francisco, California, USA.

Funding

Ocular Surface Microbiome, Virome, and Pathogens in Ophthalmic Disease and HealthK08EY026986 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DOAN, THUY A · 2016 to 2020
$1.2M
Bill and Melinda Gates FoundationNEI NIH HHS K08 EY026986Peierls FoundationResearch to Prevent BlindnessResearch to Prevent Blindness Career Development Award
6 · The paper itself

Abstract

We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs. CLINICAL TRIALS REGISTRATION: NCT02047981.

Indexed as

Anti-Bacterial AgentsAzithromycinChild, PreschoolDrug Resistance, BacterialHumansMacrolidesMass Drug AdministrationAnti-Bacterial AgentsAzithromycinMacrolidesantibiotic resistanceazithromycingut resistomemass drug distributionNigerpreschool children

Identifiers

PMID34037753
PMCPMC8492121

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.