Evidence map›Paper›PMID 34037728›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2021

Optimized implementation of cardiac resynchronization therapy: a call for action for referral and optimization of care.

Wilfried Mullens, Angelo Auricchio, Pieter Martens, Klaus Witte, Martin R Cowie, Victoria Delgado, Kenneth Dickstein, Cecilia Linde, Kevin Vernooy, Francisco Leyva and 19 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Evolution and prognosis of tricuspid and mitral regurgitation following cardiac implantable electronic devices: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Pooled it
  2. Pooled it
  3. Targeted left ventricular lead positioning to the site of latest activation in cardiac resynchronization therapy: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Pooled it
  4. Multipoint pacing is associated with reduction of heart failure hospitalizations or death in patients who do not respond to cardiac resynchronization therapy: results of the MORE-CRT MPP randomized trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Trial
  5. Multipoint pacing is associated with improved prognosis and cardiac resynchronization therapy response: MORE-CRT MPP randomized study secondary analyses.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Trial
  6. Trial
  7. Review
  8. Review
  9. Article
  10. [Left ventricular electrode placement in cardiac resynchronization therapy].Herzschrittmachertherapie & Elektrophysiologie · 2025
    Article
  11. Article
  12. Tissue characterization using cardiac magnetic resonance imaging and response to cardiac resynchronization therapy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  13. [Physiological pacing and heart failure : Hope or hype?]Herzschrittmachertherapie & Elektrophysiologie · 2025
    Review
  14. Review
  15. Article
  16. Is conduction system pacing a panacea for pacemaker therapy?Expert review of medical devices · 2024
    Review
  17. Article
  18. Assessment of ICD eligibility in non-ischaemic cardiomyopathy patients: a position statement by the Task Force of the Dutch Society of Cardiology.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024
    Review
  19. Article
  20. Is CRT Optimization Obsolete? A Referral Center's Experience.Reviews in cardiovascular medicine · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 15 countries.

Wilfried MullensZiekenhuis Oost Limburg, Genk, Belgium.
Angelo AuricchioDivision of Cardiology, Cardiocentro Ticino, Lugano, Switzerland.
Pieter MartensZiekenhuis Oost Limburg, Genk, Belgium.
Klaus WitteLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Martin R CowieImperial College London (Royal Brompton Hospital), London, UK.
Victoria DelgadoDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Kenneth DicksteinUniversity of Bergen, Stavanger University Hospital, Bergen, Norway.
Cecilia LindeHeart and Vascular Theme, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Kevin VernooyDepartment of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands.
Francisco LeyvaAston Medical School, Birmingham, UK.
Johann BauersachsDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Carsten W IsraelDepartment of Medicine - Cardiology, Diabetology and Nephrology, Bethel-Clinic, Bielefeld, Germany.
Lars H LundDepartment of Medicine Karolinska Institutet, and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Erwan DonalCardiologie, CHU Rennes - LTSI Inserm UMR 1099, Université Rennes-1, Rennes, France.
Giuseppe BorianiCardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Tiny JaarsmaJulius Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Antonio BerruezoHeart Institute, Teknon Medical Center, Barcelona, Spain.
Vassil TraykovDepartment of Cardiology, Acibadem City Clinic Tokuda Hospital, Sofia, Bulgaria.
Zaheer YousefDepartment of Cardiology, University Hospital of Wales & Cardiff University, Cardiff, UK.
Zbigniew KalarusDepartment of Cardiology, Medical University of Silesia, Katowice, Poland.
Jens Cosedis NielsenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Jan SteffelUniversitätsSpital Zürich, Zürich, Switzerland.
Panos VardasHeart Sector, Hygeia Hospitals Group, Athens, Greece.
Andrew CoatsIRCCS San Raffaele Pisana, Rome, Italy.
Petar SeferovicFaculty of Medicine, Serbian Academy of Science and Arts, Belgrade University, Belgrade, Serbia.
Thor EdvardsenDepartment of Cardiology, Oslo University Hospital, Rikshospitalet, and University of Oslo, Oslo, Norway.
Hein HeidbuchelAntwerp University and Antwerp University Hospital, Antwerp, Belgium.
Frank RuschitzkaDepartment of Cardiology, University Hospital, University Heart Center, Zurich, Switzerland.
Christophe LeclercqCardiologie, CHU Rennes - LTSI Inserm UMR 1099, Université Rennes-1, Rennes, France.
Inserm · FRKarolinska University Hospital · SEUniversity Hospital of Zurich · CHZiekenhuis Oost-Limburg · BEAarhus University Hospital · DKAntwerp University Hospital · BEAston University · GBEpatocentro Ticino · CHEvangelisches Krankenhaus Bielefeld · DEHospital Quirón Teknon · ESHygeia Hospital · GRIRCCS Ospedale San Raffaele · ITLeiden University Medical Center · NLLinköping University · SEMedical University of Silesia · PLMedizinische Hochschule Hannover · DEOslo University Hospital · NORadboud University Nijmegen · NLRoyal Brompton Hospital · GBSerbian Academy of Sciences and Arts · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac resynchronization therapy (CRT) is one of the most effective therapies for heart failure with reduced ejection fraction and leads to improved quality of life, reductions in heart failure hospitalization rates and all-cause mortality. Nevertheless, up to two-thirds of eligible patients are not referred for CRT. Furthermore, post-implantation follow-up is often fragmented and suboptimal, hampering the potential maximal treatment effect. This joint position statement from three European Society of Cardiology Associations, Heart Failure Association (HFA), European Heart Rhythm Association (EHRA) and European Association of Cardiovascular Imaging (EACVI), focuses on optimized implementation of CRT. We offer theoretical and practical strategies to achieve more comprehensive CRT referral and post-procedural care by focusing on four actionable domains: (i) overcoming CRT under-utilization, (ii) better understanding of pre-implant characteristics, (iii) abandoning the term 'non-response' and replacing this by the concept of disease modification, and (iv) implementing a dedicated post-implant CRT care pathway.

Indexed as

Cardiac Resynchronization TherapyHeart FailureCardiac Resynchronization Therapy DevicesHumansQuality of LifeReferral and ConsultationTreatment OutcomeCardiac resynchronization therapyCare pathwaysDisease managementDisease modificationHeart failureImplementationOutcomeResponseUtilization

Identifiers

PMID34037728
OpenAlexW3128173149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.