ReviewVeterinary medicine and science2021
Bovine semen sexing: Sperm membrane proteomics as candidates for immunological selection of X- and Y-chromosome-bearing sperm.
Review in Veterinary medicine and science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on the prospects of X- and Y-sexed semen in ruminant livestock: implications for conservation, a South African perspective.Frontiers in veterinary science · 2024Pooled it
- Sperm Sexing in Selected Animals and Humans: Methods, Applications, and Future Prospects.Andrology · 2026Review
- Electrospun poly(lactic acid) biopolymer fibers functionalized with Y-sperm-specific scFv enable immunoaffinity-driven bovine sperm sexing.Scientific reports · 2026Article
- Sex Determination of X and Y Separated Fresh Bull Sperm Using SRY Gene Copy Number Analysis.Veterinary medicine and science · 2026Article
- The effect of toll-like receptor 7/8 activation by ligand (R848) on morphometry, proportion of X-Y chromosome-bearing sperm, and sexed sperm quality of bucks.Open veterinary journal · 2026Article
- Toll-like receptors 7 and 8 can be targeted to enrich Y-chromosome sperm in the domestic dog.Reproduction & fertility · 2026Article
- Two decades of sperm sex-sorting in animals: A comprehensive systematic review and meta-analysis of techniques, effectiveness, and global research trends (2005-2025).Veterinary world · 2025Review
- Progress of sex control techniques in mammals†.Biology of reproduction · 2025Review
- Molecular Constraints of Sperm Sex Sorting via TLR7/8 Activation.Animals : an open access journal from MDPI · 2025Review
- Evidence against the role of toll-like receptors 7 and 8 in sex selection in mice, cattle, and humans.iScience · 2025Article
- Evaluation of aptamers binding ability towards bovine X-specific sperm.Molecular biology reports · 2025Article
- Novel single-chain fragment variable antibody targeting plasma membrane epitopes on porcine Y-chromosome-bearing sperm.Scientific reports · 2025Article
- Whole-genome bisulfite sequencing of X and Y sperm in Holstein bulls reveals differences in autosomal methylation status.BMC genomics · 2025Article
- The Surface Proteome of Bovine Unsexed and Sexed Spermatozoa.Animals : an open access journal from MDPI · 2025Article
- Advances in immunological sorting of X and Y chromosome-bearing sperm: from proteome to sex-specific proteins.Frontiers in veterinary science · 2025Review
- Exploring aptamers for targeted enrichment of X sperm in bovine: unraveling selective potential.Animal biotechnology · 2024Article
- Comparative Bioinformatic Analysis of the Proteomes of Rabbit and Human Sex Chromosomes.Animals : an open access journal from MDPI · 2024Article
- Recent advancements to increase success in assisted reproductive technologies in cattle.Animal reproduction · 2024Review
- Exploring the full potential of sperm function with nanotechnology tools.Animal reproduction · 2024Article
- Pre-implantation development of cattle embryos produced from fresh bull semen enriched for X- chromosome-bearing spermatozoa using a monoclonal antibody.Veterinary research communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of sexed semen in dairy and beef farms ensures the production of animals of the desired sex, resulting in a reduction of costs and an improvement of environmental sustainability. Several methods have been developed over the years, but most of them were abandoned due to their limited efficacy. Currently, the only commercially available method for the separation of X- and Y-chromosome-bearing sperm is fluorescence-activated cell sorting. However, this technique is expensive and has limited usefulness for the industry, considering that it cannot produce doses of sexed semen with the desired number of sperm for artificial insemination. Immunological methods have emerged as an attractive alternative to flow cytometry and proteomic knowledge of X- and Y-sperm could be useful to the development of a new method. In this review, we identify the main applications of sexed semen, describe the existing methods and highlight future research opportunities in the field. We consider that immunological methods, based on sperm cell's surface proteins differentially expressed between X- and Y-sperm, could be an interesting and promising approach to semen sexing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.