Evidence map›Paper›PMID 34037289›Full record

ArticleJournal of magnetic resonance imaging : JMRI2021

Right Ventricular Function and T1-Mapping in Boys With Duchenne Muscular Dystrophy.

Seraina A Dual, Nyasha G Maforo, Doff B McElhinney, Ashley Prosper, Holden H Wu, Shiraz Maskatia, Pierangelo Renella, Nancy Halnon, Daniel B Ennis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Seraina A DualDepartment of Radiology, Stanford University, Palo Alto, California, USA.ORCID 0000-0001-6867-8270
Nyasha G MaforoPhysics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, California, USA.ORCID 0000-0002-5741-7021
Doff B McElhinneyDepartment of Cardiothoracic Surgery, Stanford University, Palo Alto, California, USA.ORCID 0000-0001-7242-0934
Ashley ProsperDepartment of Radiological Sciences, University of California, Los Angeles, California, USA.ORCID 0000-0001-8615-5246
Holden H WuPhysics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, California, USA.ORCID 0000-0002-2585-5916
Shiraz MaskatiaDepartment of Pediatrics, Stanford University, Palo Alto, California, USA.ORCID 0000-0002-8806-1398
Pierangelo RenellaDepartment of Radiological Sciences, University of California, Los Angeles, California, USA.ORCID 0000-0002-6444-2604
Nancy HalnonDepartment of Medicine (Cardiology), University of California, Los Angeles, California, USA.ORCID 0000-0002-8370-7831
Daniel B EnnisDepartment of Radiology, Stanford University, Palo Alto, California, USA.ORCID 0000-0001-7435-1311
University of California, Los Angeles · USPalo Alto University · USCardiovascular Institute of the South · USChildren's Hospital of Orange County · USStanford University · US

Funding

Validating Cardiac MRI Biomarkers and Genotype-Phenotype Correlations for DMDR01HL131975 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENNIS, DANIEL B · 2016 to 2019
$2.5M
NHLBI NIH HHS R01 HL131975
6 · The paper itself

Abstract

backgroundClinical management of boys with Duchenne muscular dystrophy (DMD) relies on in-depth understanding of cardiac involvement, but right ventricular (RV) structural and functional remodeling remains understudied. PURPOSE: To evaluate several analysis methods and identify the most reliable one to measure RV pre- and postcontrast T1 (RV-T1) and to characterize myocardial remodeling in the RV of boys with DMD. STUDY TYPE: Prospective. POPULATION: Boys with DMD (N = 27) and age-/sex-matched healthy controls (N = 17) from two sites. FIELD STRENGTH/SEQUENCE: 3.0 T using balanced steady state free precession, motion-corrected phase sensitive inversion recovery and modified Look-Locker inversion recovery sequences. ASSESSMENT: Biventricular mass (Mi), end-diastolic volume (EDVi) and ejection fraction (EF) assessment, tricuspid annular excursion (TAE), late gadolinium enhancement (LGE), pre- and postcontrast myocardial T1 maps. The RV-T1 reliability was assessed by three observers in four different RV regions of interest (ROI) using intraclass correlation (ICC). STATISTICAL TESTS: The Wilcoxon rank sum test was used to compare RV-T1 differences between DMD boys with negative LGE(-) or positive LGE(+) and healthy controls. Additionally, correlation of precontrast RV-T1 with functional measures was performed. A P-value <0.05 was considered statistically significant.

resultsA 1-pixel thick RV circumferential ROI proved most reliable (ICC > 0.91) for assessing RV-T1. Precontrast RV-T1 was significantly higher in boys with DMD compared to controls. Both LGE(-) and LGE(+) boys had significantly elevated precontrast RV-T1 compared to controls (1543 [1489-1597] msec and 1550 [1402-1699] msec vs. 1436 [1399-1473] msec, respectively). Compared to healthy controls, boys with DMD had preserved RVEF (51.8 [9.9]% vs. 54.2 [7.2]%, P = 0.31) and significantly reduced RVMi (29.8 [9.7] g vs. 48.0 [15.7] g), RVEDVi (69.8 [29.7] mL/m DATA

conclusionPrecontrast RV-T1 is elevated in boys with DMD compared to healthy controls and is negatively correlated with RVEF. LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY: Stage 2.

Indexed as

Muscular Dystrophy, DuchenneVentricular Function, RightContrast MediaGadoliniumHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMyocardiumProspective StudiesReproducibility of ResultsStroke VolumeContrast MediaGadoliniumcardiomyopathycardiovascular magnetic resonanceDuchenne muscular dystrophylate gadolinium enhancementmyocardial remodelingT1-mapping

Identifiers

PMID34037289
PMCPMC8516686
OpenAlexW3164170148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.