ArticleThe Journal of clinical investigation1988
Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction.
Article in The Journal of clinical investigation, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Diagnostic evaluation of the MRP-8/14 for the emergency assessment of chest pain.Journal of thrombosis and thrombolysis · 2012Trial
- Differences in the suitability of published honey bee (Apis mellifera) reference genes between the African subspecies Apis mellifera scutellata and European derived Apis mellifera.Molecular ecology · 2025Article
- Sources of variability in the human platelet transcriptome.Thrombosis research · 2023Review
- Decoding the role of platelets in tumour metastasis: enigmatic accomplices and intricate targets for anticancer treatments.Frontiers in immunology · 2023Review
- Selection and Validation of Reference Genes for Pan-Cancer in Platelets Based on RNA-Sequence Data.Frontiers in genetics · 2022Article
- Article
- Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications.Scientific reports · 2018Article
- Platelet biology and receptor pathways.Journal of cardiovascular translational research · 2013Review
- Genetic dissection of platelet function in health and disease using systems biology.Hematology/oncology clinics of North America · 2013Review
- Historical perspective and future directions in platelet research.Journal of thrombosis and haemostasis : JTH · 2011Review
- The intrinsic complement regulator decay-accelerating factor modulates the biological response to vascular injury.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Application of serial analysis of gene expression to the study of human genetic disease.Human genetics · 2009Review
- Protein synthesis by platelets: historical and new perspectives.Journal of thrombosis and haemostasis : JTH · 2009Review
- Gene expression analysis of human red blood cells.International journal of medical sciences · 2009Article
- Review
- Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function.Arteriosclerosis, thrombosis, and vascular biology · 2008Review
- mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets.Blood · 2007Article
- Review
- Article
- Platelet genomics and proteomics in human health and disease.The Journal of clinical investigation · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Human platelets are derived from megakaryocytes as anucleate cells, and thus contain only vestigial amounts of RNA capable of being transcribed into protein. This has greatly hampered efforts to study directly platelet-specific gene products and their associated polymorphisms. In this report, we describe direct amplification, using the polymerase chain reaction, of platelet-derived mRNA in amounts sufficient to permit detailed analysis, such as restriction mapping and nucleotide sequencing. The ability to generate large amounts of cDNA from platelet-specific mRNA sequences should make possible direct molecular characterization of normal platelet proteins, and facilitate the investigation of a wide variety of inherited platelet disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.