ArticleCerebral cortex (New York, N.Y. : 1991)2021
Sleep Leads to Brain-Wide Neural Changes Independent of Allocentric and Egocentric Spatial Training in Humans and Rats.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Virtual Morris Water Task: Procedures and Protocols for the Assessment of Spatial Navigation and Memory.Current protocols · 2026Article
- Memory consolidation during sleep: a facilitator of new learning?Neuropsychologia · 2026Review
- Rodent maze studies: from following simple rules to complex map learning.Brain structure & function · 2024Review
- Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions.eLife · 2023Article
- Sleep strengthens resting-state functional communication between brain areas involved in the consolidation of problem-solving skills.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Disrupting ripples: Methods, results, and caveats in closed-loop approaches in rodents.Journal of sleep research · 2022Review
- Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Predictive maps in rats and humans for spatial navigation.Current biology : CB · 2022Article
- Spindle-slow oscillation coupling correlates with memory performance and connectivity changes in a hippocampal network after sleep.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Sleep is important for memory consolidation and systems consolidation in particular, which is thought to occur during sleep. While there has been a significant amount of research regarding the effect of sleep on behavior and certain mechanisms during sleep, evidence that sleep leads to consolidation across the system has been lacking until now. We investigated the role of sleep in the consolidation of spatial memory in both rats and humans using a watermaze task involving allocentric- and egocentric-based training. Analysis of immediate early gene expression in rodents, combined with functional magnetic resonance imaging in humans, elucidated similar behavioral and neural effects in both species. Sleep had a beneficial effect on behavior in rats and a marginally significant effect in humans. Interestingly, sleep led to changes across multiple brain regions at the time of retrieval in both species and in both training conditions. In rats, sleep led to increased gene expression in the hippocampus, striatum, and prefrontal cortex. In the humans, sleep led to an activity increase in brain regions belonging to the executive control network and a decrease in activity in regions belonging to the default mode network. Thus, we provide cross-species evidence for system-level memory consolidation occurring during sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.