Evidence map›Paper›PMID 34036937›Full record

ArticleeLife2021

Tendon and motor phenotypes in the

Matthew William Grol, Nele A Haelterman, Joohyun Lim, Elda M Munivez, Marilyn Archer, David M Hudson, Sara F Tufa, Douglas R Keene, Kevin Lei, Dongsu Park and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Cells · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Matthew William GrolDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-6514-9066
Nele A HaeltermanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Joohyun LimDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-9670-806X
Elda M MunivezDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Marilyn ArcherDepartment of Orthopaedics and Sports Medicine, University of Washington, Seattle, United States.
David M HudsonDepartment of Orthopaedics and Sports Medicine, University of Washington, Seattle, United States.
Sara F TufaShriners Hospital for Children, Portland, United States.
Douglas R KeeneShriners Hospital for Children, Portland, United States.
Kevin LeiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Dongsu ParkDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Cole D KuzawaDepartment of Orthopaedic Surgery, UT Health Sciences Center, Houston, United States.
Catherine G AmbroseDepartment of Orthopaedic Surgery, UT Health Sciences Center, Houston, United States.
David R EyreDepartment of Orthopaedics and Sports Medicine, University of Washington, Seattle, United States.
Brendan H LeeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-8573-4211
Baylor College of Medicine · USUniversity of Washington · USShriners Hospitals for Children - Portland · USThe University of Texas Health Science Center at Houston · US

Funding

UNDERSTANDING FXTAS AMONG MALES WITH THE FMR1 PREMUTATIONP30HD024064 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ROSENMUND, CHRISTIAN · 1988 to 2013
$29.4M
Project 3: Collagen post-translational modification and cross-linking in OIP01HD070394 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN · 2011 to 2020
$13.4M
Collagen Cross-linking in Skeletal Aging and DiseaseR37AR037318 · NIAMS · UNIVERSITY OF WASHINGTON · PI EYRE, DAVID R · 2010 to 2019
$3.4M
PATHOLOGY OF INBORN SKELETAL DISEASESR01AR037318 · NIAMS · UNIVERSITY OF WASHINGTON · PI EYRE, DAVID R · 1986 to 2009
$3.4M
WNT1 Function in Stem Cells in Osteogenesis Imperfecta and Craniofacial-Skeletal TissuesR01DE031162 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN, PARK, DONGSU · 2021 to 2025
$2.9M
Defining periosteal skeletal stem cells and novel migration mechanisms in bone regeneration and repair in vivoR01AR072018 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI PARK, DONGSU · 2018 to 2023
$2.1M
NIAMS NIH HHS R01 AR037318NIAMS NIH HHS R01 AR072018NIAMS NIH HHS R37 AR037318NICHD NIH HHS P01 HD070394NICHD NIH HHS P30 HD024064NIDCR NIH HHS R01 DE031162
6 · The paper itself

Abstract

Osteogenesis imperfecta (OI) is characterized by short stature, skeletal deformities, low bone mass, and motor deficits. A subset of OI patients also present with joint hypermobility; however, the role of tendon dysfunction in OI pathogenesis is largely unknown. Using the

Indexed as

Motor ActivityAchilles TendonActinsAge FactorsAnimalsDisease Models, AnimalExtracellular MatrixExtracellular Matrix ProteinsFibrillar CollagensGenes, RecessiveGenetic Predisposition to DiseaseHand StrengthMatrix Metalloproteinase 2MiceMice, 129 StrainMice, Inbred C57BLActinsalpha-smooth muscle actin, mouseCrtap protein, mouseExtracellular Matrix ProteinsFibrillar CollagensMatrix Metalloproteinase 2Mmp2 protein, mouseMolecular ChaperonesNF-kappa Bbehaviorcollagengeneticsgenomicsmedicinemouseosteogenesis imperfectaprogenitorstendon

Identifiers

PMID34036937
PMCPMC8186905
OpenAlexW3165553209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.