Evidence map›Paper›PMID 34036872›Full record

SynthesisUltrasonic imaging2021

Contrast-Enhanced Ultrasound Imaging of Uterine Disorders: A Systematic Review.

Barbara Stoelinga, Lynda Juffermans, Anniek Dooper, Marleen de Lange, Wouter Hehenkamp, Thierry Van den Bosch, Judith Huirne

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Ultrasonic imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Diagnosis and classification of uterine fibroids.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Barbara StoelingaAmsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.ORCID 0000-0002-6595-4433
Lynda JuffermansAmsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
Anniek DooperAmsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
Marleen de LangeAmsterdam UMC Locatie Meibergdreef, Amsterdam, The Netherlands.
Wouter HehenkampAmsterdam UMC Locatie Meibergdreef, Amsterdam, The Netherlands.
Thierry Van den BoschKatholieke Universiteit Leuven UZ Leuven, Leuven, Belgium.
Judith HuirneAmsterdam UMC Locatie De Boelelaan, Amsterdam, The Netherlands.
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLAmsterdam University Medical Centers · NLUniversitair Ziekenhuis Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine disorders are often presented with overlapping symptoms. The microvasculature holds specific information important for diagnosing uterine disorders. Conventional sonography is an established diagnostic technique in gynecology, but is limited by its inability to image the microvasculature. Contrast-enhanced ultrasound (CEUS), is capable of imaging the microvasculature by means of intravascular contrast agents; that is, gas-filled microbubbles. We provide a literature overview on the use of CEUS in diagnosing myometrial and endometrial disorders, that is, fibroids, adenomyosis, leiomyosarcomas and endometrial carcinomas, as well as for monitoring and enhancing the effectiveness of minimally invasive therapies. A systematic literature search with quality assessment was performed until December 2020. In total 34 studies were included, published between 2007 and 2020.The results entail a description of contrast-enhancement patterns obtained from healthy tissue and from malignant and benign tissue; providing a first base for potential diagnostic differentiation in gynecology. In addition it is also possible to determine the degree of myometrial invasion in case of endometrial carcinoma using CEUS. The effectiveness of minimally invasive therapies for uterine disorders can safely and accurately be assessed with CEUS. In conclusion, the abovementioned applications of CEUS are promising and it is worth further exploring its full potential for gynecology by designing innovative and methodologically high-quality clinical studies.

Indexed as

Contrast MediaLeiomyomaHumansMicrovesselsUltrasonographyContrast Mediacontrast-enhanced ultrasoundimagingmicrovasculaturesystematic reviewuterine disorders

Identifiers

PMID34036872
PMCPMC8299780
OpenAlexW3164898056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.