Evidence map›Paper›PMID 34036813›Full record

Trial reportIntegrative cancer therapies

Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial.

Jialing Zhang, Zongshi Qin, Tsz Him So, Haiyong Chen, Wing Lok Lam, Lo Lo Yam, Pui Yan Chan, Lixing Lao, Zhang-Jin Zhang

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 13 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03762694 nacompletednot on this map

The Effect of Acupuncture for Insomnia in Breast Cancer Patients Undergoing Chemotherapy: A Randomized, Wait-list Controlled Pilot Study

TypeinterventionalSponsorThe University of Hong KongRan2019 to 2020Enrolled30ConditionsInsomnia, Secondary, Breast Cancer Female, ChemotherapyArmsAcupuncture
NCT06638450 narecruitingnot on this map

Dense Cranial Electroacupuncture Stimulation Plus Body Acupuncture for Adolescents With Psychological Distress: a Randomized Controlled Trial With Observations on Salivary Oxytocin and Cortisol Changes

TypeinterventionalSponsorThe University of Hong KongRan2026 to 2028Enrolled148ConditionsPsychological Distress, InsomniaArmsDense Cranial Electroacupuncture Stimulation plus Body Acupuncture (DCEAS+BA), Minimal Acupuncture Stimulation (MAS)
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 13 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  16. Characteristics and associated factors of insomnia in gynecological cancer patients: A cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  17. Bibliometric and visual analysis of cancer-related insomnia research from 2015 to 2025.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jialing ZhangSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID 0000-0003-0900-4617
Zongshi QinSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Tsz Him SoDepartment of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Haiyong ChenSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID 0000-0002-4889-2752
Wing Lok LamSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Lo Lo YamSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Pui Yan ChanSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Lixing LaoSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Zhang-Jin ZhangSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
University of Hong Kong · HKUniversity of Hong Kong - Shenzhen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChemotherapy-associated insomnia is a highly prevalent complaint in breast cancer patients. This study was undertaken to evaluate the safety, feasibility, and preliminary effectiveness of electroacupuncture plus auricular acupressure for chemotherapy-associated insomnia in patients with breast cancer. MATERIALS AND

methodsIn this randomized, wait-list controlled trial, thirty breast cancer patients under or post chemotherapy with insomnia were randomly allocated to the acupuncture or wait-list control group. Participants in acupuncture group received electroacupuncture plus auricular acupressure treatment twice weekly for 6 weeks. Participants in wait-list group received the same regimen of treatment after 6-week of waiting period. Insomnia Severity Index (ISI) served as the primary outcome measurement. Secondary outcomes were sleep parameters recorded with sleep diary and actiwatch, as well as the scores of Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), and Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B).

resultsTwenty-eight participants completed study (13 in the acupuncture group vs 15 in the wait-list control group). At week-6 post-intervention, ISI score change from baseline showed significant between-group difference favoring acupuncture group of -2.9 points (95% CI: -5.2 to -0.6,

conclusionsAcupuncture is safe, feasible, and effective for chemotherapy-associated insomnia in breast cancer patients under or post chemotherapy. A larger sample size randomized clinical trial is warranted to confirm the present findings. CLINICAL

trial registrationNCT03762694.

Indexed as

AcupressureBreast NeoplasmsElectroacupunctureSleep Initiation and Maintenance DisordersFemaleHumansPilot ProjectsTreatment Outcomeauricular acupressurebreast cancerchemotherapy-associated insomniaelectroacupuncturewait-list controlled

Identifiers

PMID34036813
PMCPMC8161840
OpenAlexW3163965786

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.