Evidence map›Paper›PMID 34036744›Full record

ArticleMaternal & child nutrition2021

Cut-off points for serum ferritin to identify low iron stores during the first year of life in a cohort of Mexican infants.

Azucena Pérez-Acosta, Ximena Duque, Belem Trejo-Valdivia, Samuel Flores-Huerta, Sergio Flores-Hernández, Gloria Martínez-Andrade, Marco González-Unzaga, Bernardo Turnbull, Ericka Escalante-Izeta, Miguel Klünder-Klünder and 6 more

Open access · goldAbstract read
In one paragraph

Article in Maternal & child nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Azucena Pérez-AcostaUnidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.ORCID 0000-0002-4777-1414
Ximena DuqueUnidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.ORCID 0000-0002-7630-0259
Belem Trejo-ValdiviaCentro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.ORCID 0000-0003-1518-0078
Samuel Flores-HuertaUnidad de Investigación en Salud Comunitaria, Hospital Infantil de México Federico Gómez, Instituto Nacional de Salud, Ciudad de México, México.ORCID 0000-0002-8448-4721
Sergio Flores-HernándezCentro de Investigación en Evaluación y Encuestas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.ORCID 0000-0001-5773-9234
Gloria Martínez-AndradeUnidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Ciudad de México, México.ORCID 0000-0002-4579-9819
Marco González-UnzagaUnidad de Investigación en Epidemiología Nutricional, Instituto Mexicano del Seguro Social, Ciudad de México, México.ORCID 0000-0002-4355-8456
Bernardo TurnbullAcadémico de tiempo, Universidad Iberoamericana, Ciudad de México, México.ORCID 0000-0001-9663-913X
Ericka Escalante-IzetaDepartamento de Ciencias de la Salud, Universidad Iberoamericana, San Andrés Cholula, Puebla, Mexico.
Miguel Klünder-KlünderSubdirección de Investigación, Hospital Infantil de México Federico Gómez, Instituto Nacional de Salud, Ciudad de México, México.ORCID 0000-0003-1914-8366
Tania Carranco-HernándezDirección de Prestaciones Económicas y Sociales, Coordinación del Servicio de Guardería para el Desarrollo Integral Infantil, División de Desarrollo Integral Infantil, Instituto Mexicano del Seguro Social, Ciudad de México, México.
Eugenia MendozaUnidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.ORCID 0000-0002-2457-0644
Elma Ivonne Sotelo-HamCoordinación Delegacional de Investigación de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas, México.ORCID 0000-0003-2267-2062
Alicia PinedaUnidad de Investigación en Epidemiología Clínica, Instituto Mexicano del Seguro Social, Colima, México.
Carolina Medina-EscobedoDirección de Educación e Investigación en Salud. Unidad Médica de Alta Especialidad, Hospital de Especialidades Centro Médico Nacional "Ignacio García Téllez" en Mérida, Instituto Mexicano del Seguro Social, Mérida, México.ORCID 0000-0003-1203-1552
Homero MartinezDirección de Investigación, Hospital Infantil de México Federico Gómez, Instituto Nacional de Salud, Ciudad de México, México.ORCID 0000-0002-1435-0306
Mexican Social Security Institute · MXHospital Infantil de México Federico Gómez · MXInstituto Nacional de Salud Pública · MXIbero American University · MXIbero-American University Puebla · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to identify serum ferritin (SF) cut-off points (COPs) in a cohort of healthy full-term normal birth weight infants who had repeated measurements of SF and haemoglobin every 3 months during the first year of life. The study included 746 full-term infants with birth weight ≥2,500 g, having uncomplicated gestations and births. Participants received prophylactic iron supplementation (1 mg/day of iron element) from the first to the 12th month of life and did not develop anaemia during the first year of life. Two statistical methods were considered to identify COPs for low iron stores at 3, 6, 9 and 12 months of age: deviation from mean and cluster analysis. According to the K-means cluster analysis results by age and sex, COPs at 3 and 6 months for girls were 39 and 21 μg/L and for boys 23 and 11 μg/L, respectively. A single COP of 10 μg/L was identified, for girls and boys, at both 9 and 12 months. Given the physiological changes in SF concentration during the first year of life, our study identified dynamic COPs, which differed by sex in the first semester. Adequate SF COPs are necessary to identify low iron stores at an early stage of iron deficiency, which represents one of the most widespread public health problems around the world, particularly in low- and middle-income countries.

Indexed as

Anemia, Iron-DeficiencyFerritinsCohort StudiesFemaleHemoglobinsHumansInfantIronMaleFerritinsHemoglobinsIronassessment of iron statusepidemiologyinfant iron statusiron deficiencyK-means cluster analysislow iron storesnutritionpublic healthserum ferritinserum ferritin cut-off points

Identifiers

PMID34036744
PMCPMC8476433
OpenAlexW3164089634

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.