Evidence map›Paper›PMID 34036743›Full record

ArticleInternational wound journal2022

Skin substitutes with noncultured autologous skin cell suspension heal porcine full-thickness wounds in a one-stage procedure.

Sita M Damaraju, Benjamin R Mintz, J Genevieve Park, Ankur Gandhi, Sunil Saini, Joseph A Molnar

Open access · goldAbstract read
In one paragraph

Article in International wound journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sita M DamarajuProduct Development, Integra LifeSciences, Corp, Princeton, New Jersey, USA.ORCID https://orcid.org/0000-0002-7384-6053
Benjamin R MintzProduct Development, Integra LifeSciences, Corp, Princeton, New Jersey, USA.
J Genevieve ParkWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0003-4453-5827
Ankur GandhiProduct Development, Integra LifeSciences, Corp, Princeton, New Jersey, USA.
Sunil SainiProduct Development, Integra LifeSciences, Corp, Princeton, New Jersey, USA.
Joseph A MolnarWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Integra LifeSciences (United States) · USWake Forest University · US

Funding

Integra LifeSciences
6 · The paper itself

Abstract

Clinical application of skin substitute is typically a two-stage procedure with application of skin substitute matrix to the wound followed by engraftment of a split-thickness skin graft (STSG). This two-stage procedure requires multiple interventions, increasing the time until the wound is epithelialised. In this study, the feasibility of a one-stage procedure by combining bioengineered collagen-chondroitin-6-sulfate (DS1) or decellularised fetal bovine skin substitute (DS2) with autologous skin cell suspension (ASCS) in a porcine full-thickness wound healing model was evaluated. Twelve full-thickness excisional wounds on the backs of pigs received one of six different treatments: empty; ASCS; DS1 with or without ASCS; DS2 with or without ASCS. The ASCS was prepared using a point-of-care device and was seeded onto the bottom side of DS1, DS2, and empty wounds at 80 000 cells/cm

Indexed as

Skin, ArtificialAnimalsCattleRe-EpithelializationSkin TransplantationSwineTransplantation, AutologousWound Healingautologous skin cell suspensionporcineskin reconstructionskin substituteswound healing

Identifiers

PMID34036743
PMCPMC8684857
OpenAlexW3164390546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.