ArticlePlant biotechnology journal2021
BIN2 negatively regulates plant defence against Verticillium dahliae in Arabidopsis and cotton.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Unraveling the genetic basis of quantitative resistance to diseases in tomato: a meta-QTL analysis and mining of transcript profiles.Plant cell reports · 2024Pooled it
- Plant Phosphatidylinositol Signalling Network in Cotton Resistance to Verticillium Wilt.Plant, cell & environment · 2026Review
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- GhPsbO breaks the growth-immunity tradeoff by simultaneously promoting growth and defense in cotton.The Plant cell · 2026Article
- Global transcriptional and metabolic reprogramming underlies Fusarium wilt resistance in figleaf gourd (Cucurbita ficifolia).BMC genomics · 2026Article
- GbWRKY11 Enhances Verticillium Wilt Resistance Through Activating Jasmonic Acid Biosynthesis in Cotton.Molecular plant pathology · 2026Article
- Natural variation in the GhTTL promoter modulates cotton fiber elongation through the GhTALE-GhTTL-GhBIN2 module.Plant communications · 2025Article
- Transcriptome analysis unveiled the genetic basis of rapid seed germination strategies in alpine plant Rheum pumilum.Scientific reports · 2024Article
- GbPP2C80 Interacts with GbWAKL14 to Negatively Co-Regulate Resistance to Fusarium and Verticillium wilt via MPK3 and ROS Signaling in Sea Island Cotton.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Enhancing tomato fruit antioxidant potential through hydrogen nanobubble irrigation.Horticulture research · 2024Article
- iJAZ-based approach to engineer lepidopteran pest resistance in multiple crop species.Nature plants · 2024Article
- Transcriptome Analysis Reveals the Molecular Mechanisms of BR Negative Regulatory Factor StBIN2 Maintaining Tuber Dormancy.International journal of molecular sciences · 2024Article
- Hen Egg White Lysozyme (HEWL) Confers Resistance to Verticillium Wilt in Cotton by Inhibiting the Spread of Fungus and Generating ROS Burst.International journal of molecular sciences · 2023Article
- HbBIN2 Functions in Plant Cold Stress Resistance through Modulation of HbICE1 Transcriptional Activity and ROS Homeostasis inInternational journal of molecular sciences · 2023Article
- Influence of Exogenous 24-Epicasterone on the Hormonal Status of Soybean Plants.Plants (Basel, Switzerland) · 2023Article
- The CALCINEURIN B-LIKE 4/CBL-INTERACTING PROTEIN 3 module degrades repressor JAZ5 during rose petal senescence.Plant physiology · 2023Article
- Insights to Gossypium defense response against Verticillium dahliae: the Cotton Cancer.Functional & integrative genomics · 2023Review
- Spatiotemporal formation of the large vacuole regulated by the BIN2-VLG module is required for female gametophyte development in Arabidopsis.The Plant cell · 2023Article
- Post-translational modifications: emerging regulators manipulating jasmonate biosynthesis and signaling.Plant cell reports · 2023Review
- Regulatory network of GSK3-like kinases and their role in plant stress response.Frontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Verticillium wilt is caused by the soil-borne vascular pathogen Verticillium dahliae, and affects a wide range of economically important crops, including upland cotton (Gossypium hirsutum). Previous studies showed that expression levels of BIN2 were significantly down-regulated during infestation with V. dahliae. However, the underlying molecular mechanism of BIN2 in plant regulation against V. dahliae remains enigmatic. Here, we characterized a protein kinase GhBIN2 from Gossypium hirsutum, and identified GhBIN2 as a negative regulator of resistance to V. dahliae. The Verticillium wilt resistance of Arabidopsis and cotton were significantly enhanced when BIN2 was knocked down. Constitutive expression of BIN2 attenuated plant resistance to V. dahliae. We found that BIN2 regulated plant endogenous JA content and influenced the expression of JA-responsive marker genes. Further analysis revealed that BIN2 interacted with and phosphorylated JAZ family proteins, key repressors of the JA signalling pathway in both Arabidopsis and cotton. Spectrometric analysis and site-directed mutagenesis showed that BIN2 phosphorylated AtJAZ1 at T196, resulting in the degradation of JAZ proteins. Collectively, these results show that BIN2 interacts with JAZ proteins and plays a negative role in plant resistance to V. dahliae. Thus, BIN2 may be a potential target gene for genetic engineering against Verticillium wilt in crops.
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