Evidence map›Paper›PMID 34036695›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo-Dynamic Therapy.

Shoupeng Cao, Yifeng Xia, Jingxin Shao, Beibei Guo, Yangyang Dong, Imke A B Pijpers, Zhiyuan Zhong, Fenghua Meng, Loai K E A Abdelmohsen, David S Williams and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
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  11. Article
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  14. Polymer Vesicles with Integrated Photothermal Responsiveness.Journal of the American Chemical Society · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Light-Activated Membrane Transport in Polymeric Cell-Mimics.Angewandte Chemie (International ed. in English) · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shoupeng CaoBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.
Yifeng XiaBiomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
Jingxin ShaoBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.
Beibei GuoBiomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
Yangyang DongBiomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
Imke A B PijpersBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.
Zhiyuan ZhongBiomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
Fenghua MengBiomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
Loai K E A AbdelmohsenBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.
David S WilliamsSchool of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Jan C M van HestBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600, MB, Eindhoven, The Netherlands.ORCID 0000-0001-7973-2404

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biodegradable nanostructures displaying aggregation-induced emission (AIE) are desirable from a biomedical point of view, due to the advantageous features of loading capacity, emission brightness, and fluorescence stability. Herein, biodegradable polymers comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-P(CLgTMC)), with tetraphenylethylene pyridinium-TMC (PAIE) side chains have been developed, which self-assembled into well-defined polymersomes. The resultant AIEgenic polymersomes are intrinsically fluorescent delivery vehicles. The presence of the pyridinium moiety endows the polymersomes with mitochondrial targeting ability, which improves the efficiency of co-encapsulated photosensitizers and improves therapeutic index against cancer cells both in vitro and in vivo. This contribution showcases the ability to engineer AIEgenic polymersomes with structure inherent fluorescence and targeting capacity for enhanced photodynamic therapy.

Indexed as

Antineoplastic AgentsBenzylidene CompoundsBiodegradable PlasticsBoron CompoundsCell Line, TumorFluorescent DyesHumansLightPhotosensitizing AgentsPolyestersPolyethylene GlycolsPyridinium Compounds4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAntineoplastic AgentsBenzylidene CompoundsBiodegradable PlasticsBoron CompoundsFluorescent DyesPhotosensitizing AgentsPolyestersPolyethylene GlycolsPyridinium Compoundsaggregation-induced emissionbiodegradable polymersomesmitochondria targetingphoto-dynamic therapypolycarbonates

Identifiers

PMID34036695
PMCPMC8361757

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.