ArticleNeurourology and urodynamics2021
Recurrent urinary tract infection: Association of clinical profiles with urobiome composition in women.
Article in Neurourology and urodynamics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05557279 (Urinary Microbiome Changes Following Administration of 500 mg of NDS-446 in Women With Dry OAB at 12 Weeks - a Single-center Study), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urinary Microbiome Changes Following Administration of 500 mg of NDS-446 in Women With Dry OAB at 12 Weeks - a Single-center Study
Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Characterizing the role of the urobiome in the pathogenesis of recurrent urinary tract infections (rUTIs): a systematic review.International urology and nephrology · 2026Review
- The Urogenital Microbiome-Metabolic Interface in Postmenopausal Recurrent Urinary Tract Infection: Estrogen Deficiency, Diabetes, Obesity, and Microbial Reservoirs.Journal of clinical medicine · 2026Review
- More than an infection: the ecological puzzle of recurrent urinary tract infections.Frontiers in cellular and infection microbiology · 2026Review
- The Urinary Microbiota and the Gut-Bladder Axis in Bladder Cancer.International journal of molecular sciences · 2025Review
- The urinary microbiome: the next frontier of bacterial ecology.Journal of bacteriology · 2025Review
- The evaluation of antimicrobial resistance rates in infections caused by uropathogenicIranian journal of microbiology · 2025Article
- Draft genomes ofMicrobiology resource announcements · 2024Article
- Draft genomes of oneMicrobiology resource announcements · 2024Article
- Draft genome sequences of fourMicrobiology resource announcements · 2024Article
- Draft genomes ofMicrobiology resource announcements · 2024Article
- Synthesis of current pediatric urinary microbiome research.Frontiers in pediatrics · 2024Review
- Pathophysiologic Insights into the Transition from Asymptomatic Bacteriuria to Urinary Tract Infection.Current urology reports · 2023Review
- Microbiota Ecosystem in Recurrent Cystitis and the Immunological Microenvironment of Urothelium.Healthcare (Basel, Switzerland) · 2023Review
- Application of Various Techniques to Gain Insights Into the Complex Urinary Tract Microbial Communities of Renal Transplant Recipients.Transplantation direct · 2023Article
- Cataloging variation in 16S rRNA gene sequences of female urobiome bacteria.Frontiers in urology · 2023Article
- Comparative genomic analysis of uropathogenicFrontiers in microbiology · 2023Article
- Clinical relevance of expanded quantitative urine culture in health and disease.Frontiers in cellular and infection microbiology · 2023Review
- Recurrent urinary tract infection and estrogen shape the taxonomic ecology and function of the postmenopausal urogenital microbiome.Cell reports. Medicine · 2022Article
- The Urobiome and Its Role in Overactive Bladder.International neurourology journal · 2022Article
- Bladder cancer, inflammageing and microbiomes.Nature reviews. Urology · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
aimsClinical profiles of women with recurrent urinary tract infection (RUTI) are correlated with their urinary microbes.
methodsThis IRB-approved, cross-sectional study enrolled adult women with RUTI. Urine samples (catheterized and voided) underwent culture by expanded quantitative urine culture (EQUC) and standard urine culture (SUC) methods. A validated symptom questionnaire, relevant clinical variables, and EQUC were used to identify symptom clusters and detect associations with specific urinary microbes.
resultsMost (36/43) participants were postmenopausal; the average age was 67 years. 51% reported vaginal estrogen use; 51% reported sexual activity. Although single symptoms were not associated with specific urinary microbes, EQUC results were correlated with five distinct clinical profile clusters: Group A: odor, cloudiness, and current vaginal estrogen use (no culture result association). Group B: frequency, low back pain, incomplete emptying, and vaginal estrogen (significantly increased proportion of Lactobacillus-positive cultures). Group C: pain/burning, odor, cloudiness, and urgency (high proportions of UTI-associated microbe-positive cultures). Group D: frequency, urgency, pain/burning, and current vaginal estrogen use (increased number of no growth cultures). Group E: frequency, urgency, pain/burning, odor, overactive bladder, and sexually active (significantly increased proportion of Klebsiella-positive cultures).
conclusionsDistinct clinical profiles are associated with specific urinary microbes in women with RUTI. Refined assessments of clinical profiles may provide useful insights that could inform diagnostic and therapeutic considerations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.