Evidence map›Paper›PMID 34036481›Full record

ReviewMolecular biology reports2021

The protective roles of clusterin in ocular diseases caused by obesity and diabetes mellitus type 2.

Thaís Dantis Pereira de Campos, Kellen Cristina da Cruz Rodrigues, Rodrigo Martins Pereira, Chadi Pellegrini Anaruma, Raphael Dos Santos Canciglieri, Diego Gomes de Melo, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Pauli and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Thaís Dantis Pereira de CamposLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil.ORCID http://orcid.org/0000-0002-9426-874X
Kellen Cristina da Cruz RodriguesLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil.
Rodrigo Martins PereiraLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil.
Chadi Pellegrini AnarumaLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil.
Raphael Dos Santos CanciglieriLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil.
Diego Gomes de MeloLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil.
Adelino Sanchez Ramos da SilvaSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Dennys Esper CintraLaboratory of Nutritional Genomics (LABGeN), School of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Eduardo Rochete RopelleLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil.
José Rodrigo PauliLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil.
Leandro Pereira de MouraLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas, 1300 Pedro Zaccaria Street, Limeira, SP, Brazil. mouralp@unicamp.br.ORCID http://orcid.org/0000-0003-3211-1058
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade de Ribeirão Preto · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015 / 07199-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2018 / 06833-8
6 · The paper itself

Abstract

Obesity is a chronic, non-transmissible and multifactorial disease commonly associated with systemic inflammation and damage to health. This disorder has been pointed out as leading to the development of a diversity of eye diseases and, consequently, damage to visual acuity. More specifically, cardiometabolic risk is associated with lacrimal gland dysfunctions, since it changes the inflammatory profile favoring the development and worsening of dry eye disease. In more severe and extreme cases, obesity, inflammation, and diabetes mellitus type 2 can trigger the total loss of vision. In this scenario, besides its numerous metabolic functions, clusterin, an apolipoprotein, has been described as protective to the ocular surface through the seal mechanism. Thus, the current review aimed to explain the role of clusterin in dry eye disease that can be triggered by obesity and diabetes.

Indexed as

ApolipoproteinsClusterinDiabetes Mellitus, Type 2Dry Eye SyndromesEyeHumansInflammationObesityApolipoproteinsCLU protein, humanClusterinClusterinDiabetes mellitusEyeLacrimal filmRetina

Identifiers

PMID34036481
OpenAlexW3164900038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.