ArticlePediatric nephrology (Berlin, Germany)2021
Incidence and risk factors for chronic kidney disease in patients with congenital heart disease.
Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Relationship Between Central Venous Pressure, Cardiac Index, and Renal Function in Pediatric Heart Failure: a Pediatric Heart Transplant Society Study.Pediatric cardiology · 2026Article
- Lack of association between Triglyceride glucose-body mass index and glomerular filtration rate in patients with coronary heart disease after percutaneous coronary intervention: a retrospective case-control study.Frontiers in endocrinology · 2026Article
- Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations.Nature biomedical engineering · 2025Article
- Successful living donor kidney transplantation in a 14-year-old boy with Fontan circulation.Pediatric nephrology (Berlin, Germany) · 2025Article
- Microalbuminuria in children with cyanotic congenital heart disease in Enugu, Nigeria; a comparative study.BMC nephrology · 2025Article
- Kidney Transplantation in Congenital Heart Disease Patients: What Are the Outcomes?Pediatric transplantation · 2025Article
- Kidney transplant outcomes in children with simultaneous versus sequential heart-kidney transplants.Pediatric nephrology (Berlin, Germany) · 2024Article
- Case report: Challenging kidney transplantation in an adolescent patient with tetralogy of Fallot.Frontiers in medicine · 2024Article
- Identification ofDiagnostics (Basel, Switzerland) · 2022Article
- Kidney disease and congenital heart disease: Partnership for life.Frontiers in physiology · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundsChronic kidney disease (CKD) is underdiagnosed in children with congenital heart disease (CHD). Our aim was to study the incidence of CKD in CHD children and identify risk factors for CKD.
methodsCHD patients were enrolled from the Kaohsiung Veterans General Hospital database between 2010 and 2019. Patient age at enrollment was age at first visit to the hospital. The end of follow-up was marked by the last measurement of serum creatinine, urine protein-to-creatinine ratio (UPCR), or urine microalbumin-to-creatinine ratio (UACR) after enrollment, and only patients who underwent the aforementioned tests in 2 different years were included. Patients with an estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73m
resultsThe study included 359 CHD patients, of whom 167 (46.5%) developed CKD (18 patients with CR-CKD and 341 with NCR-CKD). Patients with CR-CKD were significantly older at enrollment than patients with NCR-CKD. Corrective heart surgery may be a protective factor for CKD. Furthermore, cyanotic heart disease, two or more image-related contrast exposures, and diuretic use may be associated with CKD.
conclusionCHD patients have a high incidence of CKD. The early detection of CKD and prompt corrective heart surgery for CHD may be beneficial for kidney function.
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