Evidence map›Paper›PMID 34036439›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Fear of cancer recurrence in patients undergoing germline genome sequencing.

Nicci Bartley, Grace Davies, Phyllis Butow, Christine E Napier, Tim Schlub, Mandy L Ballinger, David M Thomas, Ilona Juraskova, Bettina Meiser, Megan C Best

Abstract read
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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicci BartleySchool of Psychology, The University of Sydney, Sydney, NSW, Australia. nicole.bartley@sydney.edu.au.ORCID http://orcid.org/0000-0001-9052-1616
Grace DaviesSchool of Psychology, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-7867-3780
Phyllis ButowSchool of Psychology, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-3562-6954
Christine E NapierCancer Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-8009-7735
Tim SchlubSchool of Psychology, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-7746-9649
Mandy L BallingerCancer Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9706-0514
David M ThomasCancer Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-2527-5428
Ilona JuraskovaSchool of Psychology, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-9396-4113
Bettina MeiserPrince of Wales Clinical School, University of NSW, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-5086-0784
Megan C BestSchool of Psychology, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-1570-8872

Funding

Cancer Institute NSW CDF171109Cancer Institute NSW MB00352National Health and Medical Research Council 1078523National Health and Medical Research Council 1104364National Health and Medical Research Council 1121630National Health and Medical Research Council 1124749
6 · The paper itself

Abstract

purposeFear of cancer recurrence/occurrence (FCR/O) is prevalent and associated with poorer psychological outcomes but can also motivate individuals to pursue genomic information about cancer risk. Guided by Protection Motivation Theory, this study investigated FCR/O prevalence and associated factors among probands previously diagnosed with a cancer of likely heritable origin, and their relatives, who had agreed to have germline genome sequencing.

methodsThree hundred and forty-eight probands and 167 relatives completed the Concerns about Recurrence Questionnaire (adapted for occurrence for some relatives) within 1 month of agreeing to undertake genome sequencing. Linear regressions investigated demographic, disease, attitude and behavioral associations with FCR/O.

resultsProbands demonstrated greater FCR compared to relatives. In probands, greater FCR was associated with being female, non-English speaking at home, less time since diagnosis, greater intention to change behavior if gene variant found, lower perceived ability to cope with results, higher perceived susceptibility to having a recurrence, and more negative attitudes towards uncertainty. For relatives with cancer, greater FCR was associated with being male, greater intention to change behavior if a gene variant found, and higher perceived susceptibility to recurrence. In relatives without cancer, greater FCO was associated with not having had genetic testing prior to this study, lower perceived ability to cope with results, and higher perceived susceptibility to developing cancer.

conclusionCurrent findings on FCR/O prevalence and associated demographic and attitudinal variables in those who pursue genomic risk information might be used to target interventions that can prevent adverse psychological outcomes in vulnerable patients.

Indexed as

Neoplasm Recurrence, LocalPhobic DisordersAdaptation, PsychologicalFearFemaleGerm CellsHumansMaleCancerFear of cancer recurrenceGenomicsOncologyPsycho-oncologyRisk

Identifiers

PMID34036439

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.