Evidence map›Paper›PMID 34036434›Full record

Trial reportClinical oral investigations2022

Therapeutic effect of a novel bioactive glass-ceramics on early caries lesions: a single-center, randomized controlled clinical trial.

Xiangyu Guo, Xue Li, Chunjuan Liao, Kun He, Yisi Zhong, Tao He

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiangyu GuoState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610000, China.
Xue LiState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610000, China.
Chunjuan LiaoState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610000, China.
Kun HeState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610000, China.
Yisi ZhongState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610000, China.
Tao HeState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610000, China. he_tao6688@126.com.ORCID http://orcid.org/0000-0002-2241-1834
Sichuan University · CN

Funding

Health Department of Sichuan Province (CN) 19PJ074
6 · The paper itself

Abstract

objectivesTo investigate the therapeutic effect of a novel bioactive glass-ceramics (BGC) called Huaxi BGC (HX-BGC) on early caries lesions. MATERIALS AND

methodsA total of 195 patients who meeting inclusion criteria were recruited and randomized to three groups in a 1:1:1 ratio. The patients in the treatment group received fluoride varnish which contained 5% sodium fluoride (NaF) or distilled water which contained 7.5% HX-BGC once a month for 3 months, and the control group received placebos. Quantitative light-induced fluorescence (QLF) images were taken at baseline and at the 1-month and 3-month follow-ups.

resultsThe three groups had similar baseline characteristics, including age, gender, and QLF parameters (ΔF, area, and ΔQ). Compared with baseline, the ΔQ values were significantly decreased in the HX-BGC and NaF groups at 1 and 3 months (p<0.005), while no statistically significant changes were found in that of the control group. After adjusting for baseline measurements, both of the 5% NaF and 7.5% HX-BGC showed a significant therapeutic effect in the treatment of initial enamel lesions at 1 month and 3 months, when compared to those receiving placebos (ΔQ, p<0.05). Moreover, the ΔQ value of the HX-BGC group decreased by a slightly more amount than that of the NaF group at 1 month (p=0.048). Similar trends were also found for the values of ΔF and area.

conclusionOur results suggest that HX-BGC may serve as a promising bioactive material for the treatment of early caries lesions. CLINICAL RELEVANCE: HX-BGC holds a great promise to be used as a novel bioactive material for the treatment of early caries lesions.

Indexed as

Dental CariesDental Caries SusceptibilityCariostatic AgentsCeramicsFluoridesHumansSodium FluorideCariostatic AgentsFluoridesSodium FluorideBioactive glass-ceramicsDental cariesFluorideHX-BGCQuantitative light-induced fluorescence

Identifiers

PMID34036434
OpenAlexW3165271850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.