Evidence map›Paper›PMID 34036420›Full record

ArticleEuropean radiology2021

Prognostic value of response evaluation based on breast MRI after neoadjuvant treatment: a retrospective cohort study.

Almir G V Bitencourt, Barbara S Pires, Vinicius F Calsavara, Erika M S Negrão, Juliana A Souza, Luciana Graziano, Camila S Guatelli, Fabiana B Makdissi, Solange M Sanches, Monique C Tavares and 4 more

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Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Almir G V BitencourtDepartment of Imaging, A.C.Camargo Cancer Center, São Paulo, Brazil. almir.bitencourt@accamargo.org.br.ORCID http://orcid.org/0000-0003-0192-9885
Barbara S PiresAnhembi-Morumbi University, São Paulo, Brazil.
Vinicius F CalsavaraDepartment of Epidemiology and Statistics, A.C.Camargo Cancer Center, São Paulo, Brazil.
Erika M S NegrãoPrevention Institute, Hospital de Amor de Barretos, Campinas, Brazil.
Juliana A SouzaDepartment of Imaging, A.C.Camargo Cancer Center, São Paulo, Brazil.
Luciana GrazianoDepartment of Imaging, A.C.Camargo Cancer Center, São Paulo, Brazil.
Camila S GuatelliDepartment of Imaging, A.C.Camargo Cancer Center, São Paulo, Brazil.
Fabiana B MakdissiDepartment of Breast Surgery, A.C.Camargo Cancer Center, São Paulo, Brazil.
Solange M SanchesDepartment of Clinical Oncology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Monique C TavaresDepartment of Clinical Oncology, A.C.Camargo Cancer Center, São Paulo, Brazil.
Cynthia A B T OsórioDepartment of Pathology , A.C.Camargo Cancer Center , São Paulo, Brazil.
Marina De BrotDepartment of Pathology , A.C.Camargo Cancer Center , São Paulo, Brazil.
Elvira F MarquesDepartment of Imaging, A.C.Camargo Cancer Center, São Paulo, Brazil.
Rubens ChojniakDepartment of Imaging, A.C.Camargo Cancer Center, São Paulo, Brazil.
AC Camargo Hospital · BRAnhembi Morumbi University · BRHospital de Câncer de Barretos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the impact of response evaluation after neoadjuvant chemotherapy (NAC) in breast cancer patients, assessed by both magnetic resonance imaging (MRI) and pathology, on disease-free survival (DFS).

methodsThis single-center, retrospective cohort study included consecutive breast cancer patients who underwent NAC and preoperative breast MRI. Resolution of invasive carcinoma in the breast and axilla was defined as complete pathological response (pCR). Radiological complete response (rCR) was defined as the absence of abnormal enhancement in the tumor site. Kaplan-Meier estimator was used to estimate the disease-free survival on 60 months. Cox regression analysis was used to estimate hazard ratio (HR) values.

resultsIn total, 317 patients were included with a mean age of 47.3 years and a mean tumor size of 39.8 mm. The most common immunophenotype was luminal (44.9%), followed by triple-negative (26.8%). Overall, 126 patients (39.7%) had an rCR, while 119 (37.5%) had pCR; the radiological and pathological responses agreed in 252 cases (79.5%). During follow-up, patients who had rCR and pCR had a better DFS curve compared to patients with non-rCR and non-pCR, while those who had rCR or pCR presented an intermediate curve (Log-rank p = 0.003). Multivariate analysis showed a higher risk of recurrence in patients with non-rCR and non-pCR (HR: 5,626; p = 0.020) and those who had a complete response on MRI or pathology only (HR: 4,369; p = 0.067), when compared to patients with rCR and pCR.

conclusionsThe association of MRI and pathological responses after NAC might better stratify the risk of recurrence and prognosis in breast cancer patients. KEY POINTS: • Association of response evaluation after neoadjuvant chemotherapy by pathology and MRI allows better stratification of prognosis. • Complete response to neoadjuvant chemotherapy on pathology and MRI was related to better disease-free survival. • Complete response on MRI or pathology only had a greater risk of recurrence.

Indexed as

Breast NeoplasmsNeoadjuvant TherapyAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantFemaleHumansMagnetic Resonance ImagingMiddle AgedNeoplasm Recurrence, LocalPrognosisRetrospective StudiesTreatment OutcomeBreast neoplasmsMagnetic resonance imagingNeoadjuvant therapy

Identifiers

PMID34036420
OpenAlexW3164642167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.