Evidence map›Paper›PMID 34036399›Full record

ArticleOncology reports2021

AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization.

Xingjie Chen, Yalin Lu, Gaochao Guo, Yu Zhang, Yan Sun, Lianmei Guo, Ruohong Li, Yang Nan, Xuejun Yang, Jun Dong and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Xingjie Chen *Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Yalin Lu *Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Gaochao Guo *Department of Neurosurgery, Henan Provincial People's Hospital, Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
Yu ZhangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Yan SunDepartment of Neurosurgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China.
Lianmei GuoDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Ruohong LiDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Yang NanDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Xuejun YangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Jun DongDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China.
Xun JinTianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China.
Qiang HuangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Tianjin Medical University General Hospital · CNHenan Provincial People's Hospital · CNQingdao University · CNSecond Affiliated Hospital of Soochow University · CNTianjin Medical University Cancer Institute and Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is the most prevalent type of malignant cancer in the adult central nervous system; however, its mechanism remains unclear. Angiomotin‑like 2 (AMOTL2) is a member of the motin family of angiostatin‑binding proteins. It has been reported as an oncogene in cervical and breast cancer, but its association with glioma remains unknown. The aim of the present study was to investigate AMOTL2‑regulated processes in glioma cell lines using extensive

Indexed as

Down-RegulationAdultAngiomotinsbeta CateninBrain NeoplasmsCarrier ProteinsCell Line, TumorCell MovementCell NucleusCell ProliferationEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGliomaHumansAMOTL2 protein, humanAngiomotinsbeta CateninCarrier ProteinsCTNNB1 protein, humanangiomotin‑like 2bioinformaticsglioblastomanucleus translocationWnt/β‑catenin signaling

Identifiers

PMID34036399
PMCPMC8165599
OpenAlexW3164837265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.