ArticleMolecular medicine reports2021
Endoplasmic reticulum stress promotes epithelial‑mesenchymal transition via the PERK signaling pathway in paraquat‑induced pulmonary fibrosis.
Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Reactive oxygen species-evoked endoplasmic reticulum stress mediates albumin load-induced epithelial-mesenchymal transition in podocytes.Molecular biology reports · 2026Article
- Developments in the connection between epithelial‑mesenchymal transition and endoplasmic reticulum stress (Review).International journal of molecular medicine · 2025Review
- Luteolin Protects Against 6-Hydoroxydopamine-Induced Cell Death via an Upregulation of HRD1 and SEL1L.Neurochemical research · 2024Article
- Endoplasmic Reticulum Stress and the Lysosomal Pathway Play Crucial Roles in the Progression of βB2-Crystallin Mutation-Induced Congenital Cataracts in Mice.Investigative ophthalmology & visual science · 2023Article
- NEAT1-SOD2 Axis Confers Sorafenib and Lenvatinib Resistance by Activating AKT in Liver Cancer Cell Lines.Current issues in molecular biology · 2023Article
- Comprehensive analysis of an endoplasmic reticulum stress-related gene prediction model and immune infiltration in idiopathic pulmonary fibrosis.Frontiers in immunology · 2023Article
- A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis.Nature cell biology · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary fibrosis is the primary reason for mortality in patients with paraquat (PQ) poisoning. Our previous study demonstrated that epithelial‑mesenchymal transition (EMT) had a role in PQ‑induced pulmonary fibrosis. However, the role of endoplasmic reticulum (ER) stress in PQ‑induced EMT remains clear. The present study aimed to determine the role of ER stress in EMT in PQ‑induced pulmonary fibrosis. A549 and RLE‑6TN cells were incubated with LY294002 (a PI3K inhibitor) or transfected with protein kinase RNA‑like ER kinase (PERK) small interfering RNA (si) for 24 h prior to being exposed to PQ. Next, the expression levels of ER stress‑related proteins, PI3K/AKT/GSK‑3β signaling pathway‑related proteins and EMT‑related markers were analyzed by performing western blotting, reverse transcription‑quantitative PCR and immunofluorescence assays. The results of the present study revealed that the protein expression levels of PERK, phosphorylated (p)‑PERK, p‑eukaryotic initiation factor 2 (eIF2)α were significantly upregulated in the PQ group, whereas p‑PI3K, p‑AKT and p‑GSK‑3β were significantly upregulated in the sicontrol + PQ group compared with the sicontrol group.
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