ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Cumulative Incidence of Infective Endocarditis in Patients with Congenital Heart Disease: A Nationwide, Case-Control Study Over Nine Decades.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Utility of FDG PET/CT for detection of infective endocarditis in pediatric and young adult congenital heart disease.European journal of nuclear medicine and molecular imaging · 2026Article
- In-hospital Outcomes of Pediatric Cardiac Surgery Admissions for Acute Infective Endocarditis in Congenital Heart Disease.Pediatric cardiology · 2026Article
- Clinical Features and Outcomes of Surgically Treated Infective Endocarditis in Adults with and Without Congenital Heart Disease: A 12-Year Cohort Study.Journal of cardiovascular development and disease · 2026Article
- Infective Endocarditis: A Contemporary Review of Epidemiology, Diagnosis, and Management.Antibiotics (Basel, Switzerland) · 2026Review
- Sustained Effector Functions and Memory Accumulation of αβ T Cells in Children With Congenital Heart Disease.European journal of immunology · 2026Article
- Endocarditis in Adults with Congenital Heart Disease.Methodist DeBakey cardiovascular journal · 2026Review
- Infective Endocarditis in Special Populations: Epidemiology, Diagnostic Challenges, and Management Strategies.Cureus · 2025Review
- Cardiovascular magnetic resonance in Tetralogy of Fallot-state of the art.Cardiovascular diagnosis and therapy · 2025Review
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Case Report: A new therapeutic option for a rare patent ductus arteriosus child complicated with pulmonary artery aneurysm due to infectious endocarditis.Frontiers in cardiovascular medicine · 2025Article
- D-Transposition of Great Arteries With Infective Endocarditis and Congestive Cardiac Failure: A Case Report.Cureus · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- SomaticExperimental and therapeutic medicine · 2024Article
- Infective Endocarditis among Pediatric Patients with Prosthetic Valves and Cardiac Devices: A Review and Update of Recent Emerging Diagnostic and Management Strategies.Journal of clinical medicine · 2023Review
- Surgical Atrial Septal Patch Endocarditis in a Patient with a Complete Corrected Atrioventricular Canal Defect: A Case Report and Review of the Literature.Diagnostics (Basel, Switzerland) · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Discovery ofBiology · 2023Article
- Identification ofDiagnostics (Basel, Switzerland) · 2022Article
- Infective Endocarditis in High-Income Countries.Metabolites · 2022Review
- Pediatric Infective Endocarditis: A Literature Review.Journal of clinical medicine · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCongenital heart disease (CHD) is a lifelong predisposing condition for infective endocarditis (IE). As a consequence of advances in pediatric care, the number of adults with CHD is now exceeding the number of children. The goal of the present study was to determine the cumulative incidence of IE in patients with CHD and detect temporal changes compared with controls.
methodsNationwide registry-based case-control study of patients with CHD born 1930-2017 matched with 10 random controls. Infective endocarditis episodes were linked using the Swedish 10-digit personal identification number.
resultsIn total, 89 541 patients with CHD and 890 470 matched controls were included. In patients with CHD, 1477 IE episodes were registered and 447 episodes in controls. Patients with CHD had 8.5% cumulative incidence of IE at age 87 years, compared with 0.7% in matched controls. Incidence rate of IE per 100 000 person-years was 65.5 (95% confidence interval [CI] 62.2-68.9) and 1.8 (95% CI: 1.7-2.0) in CHD patients and controls, respectively. By age 18 years, patients with CHD had an IE incidence similar to that of 81-year-old controls. Incidence of IE differed by age but not by birth year. Bacterial etiology was registered from 1997 in half of the IE episodes; among CHD IE cases, 43.3% were caused by streptococci and 29.8% by Staphylococcus aureus.
conclusionsInfective endocarditis remains an important complication in patients with CHD. Incidence correlate with age and the number of IE episodes are expected to increase as the CHD population grow older.
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