Evidence map›Paper›PMID 34036268›Full record

ArticleCritical care explorations2021

Treatment of Bronchopleural and Alveolopleural Fistulas in Acute Respiratory Distress Syndrome With Extracorporeal Membrane Oxygenation, a Case Series and Literature Review.

Mazen F Odish, Jenny Yang, George Cheng, Cassia Yi, Eugene Golts, Michael Madani, Travis Pollema, Robert L Owens

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07673250 (Personalized Ventilator Settings for Patients on ECMO), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07673250 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Personalized Ventilator Settings for Patients on ECMO (PEEPECMO)

TypeinterventionalSponsorUniversity of California, San DiegoRan2026 to 2031Enrolled62ConditionsAcute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICUArmsPersonalized Positive End-Expiratory Pressure (PEEP)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. HFOV in inhalational injury associated ARDS with broncho-pleural fistula - An old friend to the rescue: Case report.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023
    Article
  4. Extracorporeal membrane oxygenation in children: A brief review.Journal of paediatrics and child health · 2022
    Review
  5. Tension pneumomediastinum from opioid inhalation.The American journal of emergency medicine · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mazen F OdishDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, UC San Diego, La Jolla, CA.
Jenny YangDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, UC San Diego, La Jolla, CA.
George ChengDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, UC San Diego, La Jolla, CA.
Cassia YiDepartment of Nursing, UC San Diego Health, La Jolla, CA.
Eugene GoltsDepartment of Surgery, Division of Cardiovascular and Thoracic Surgery, UC San Diego, La Jolla, CA.
Michael MadaniDepartment of Surgery, Division of Cardiovascular and Thoracic Surgery, UC San Diego, La Jolla, CA.
Travis PollemaDepartment of Surgery, Division of Cardiovascular and Thoracic Surgery, UC San Diego, La Jolla, CA.
Robert L OwensDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, UC San Diego, La Jolla, CA.
UC San Diego Health System · US

Funding

Obstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living with HIVR01HL142114 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR, OWENS, ROBERT LLEWELLYN · 2018 to 2021
$2.0M
Interdisciplinary Anesthesiology Research Training ProgramT32GM121318 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hemal H Patel, DAVID M ROTH · 2017 to 2026
$1.5M
NHLBI NIH HHS R01 HL142114NIGMS NIH HHS T32 GM121318
6 · The paper itself

Abstract

objectivesTo describe a ventilator and extracorporeal membrane oxygenation management strategy for patients with acute respiratory distress syndrome complicated by bronchopleural and alveolopleural fistula with air leaks. DESIGN SETTING AND

participantsCase series from 2019 to 2020. Single tertiary referral center-University of California, San Diego. Four patients with various etiologies of acute respiratory distress syndrome, including influenza, methicillin-resistant MEASUREMENTS AND MAIN

resultsBronchopleural and alveolopleural fistula closure and survival to discharge. All four patients were placed on extracorporeal membrane oxygenation with ventilator settings even lower than Extracorporeal Life Support Organization guideline recommended ultraprotective lung ventilation. The patients bronchopleural and alveolopleural fistulas closed during extracorporeal membrane oxygenation and minimal ventilatory support. All four patients survived to discharge.

conclusionsIn patients with acute respiratory distress syndrome and bronchopleural and alveolopleural fistula with persistent air leaks, the use of extracorporeal membrane oxygenation to allow for even lower ventilator settings than ultraprotective lung ventilation is safe and feasible to mediate bronchopleural and alveolopleural fistula healing.

Indexed as

acute respiratory distress syndromebarotraumaextracorporeal membrane oxygenationpneumothoraxthoracostomy

Identifiers

PMID34036268
PMCPMC8133109
OpenAlexW3160931602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.