Evidence map›Paper›PMID 34036264›Full record

ArticleRadiology. Cardiothoracic imaging2020

Pulmonary Vascular Manifestations of COVID-19 Pneumonia.

Min Lang, Avik Som, Denston Carey, Nicholas Reid, Dexter P Mendoza, Efrén J Flores, Matthew D Li, Jo-Anne O Shepard, Brent P Little

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04732663 completednot on this mapstarted 2021, after this paper: background citation

Understanding Exertional Dyspnea and Exercise Intolerance in COVID-19

TypeobservationalSponsorUniversity of AlbertaRan2021 to 2024Enrolled64ConditionsCovid19, DyspneaArmsNo Intervention
NCT05304702 completednot on this mapstarted 2021, after this paper: background citation

Lung Injury (Pulmonary Edema) in COVID-19: Treatment With Furosemide and Negative Fluid Balance (NEGBAL): a Case-Control Study

TypeobservationalSponsorClinica ColonRan2021 to 2022Enrolled120ConditionsCOVID-19
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Subsegmental vascular dilatations: An important finding in COVID-19 pneumonia.Revista da Sociedade Brasileira de Medicina Tropical · 2026
    Article
  5. Article
  6. Review
  7. Coronary Implications of COVID-19.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
    Review
  8. Forward Computational Modeling of Respiratory Airflow.Applied sciences (Basel, Switzerland) · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. The impact of acute COVID-19 on the retinal microvasculature assessed with multimodal imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. CT-Angiographic Aspects of Pulmonary Embolism on SARS COV-2.Journal of the Belgian Society of Radiology · 2023
    Article
  19. Article
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Min LangDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.L., A.S., D.P.M., E.J.F., M.D.L., J.O.S., B.P.L.); and Harvard Medical School, Boston, Mass (D.C., N.R.).ORCID https://orcid.org/0000-0002-3895-5342
Avik SomDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.L., A.S., D.P.M., E.J.F., M.D.L., J.O.S., B.P.L.); and Harvard Medical School, Boston, Mass (D.C., N.R.).ORCID https://orcid.org/0000-0002-2198-7575
Denston CareyDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.L., A.S., D.P.M., E.J.F., M.D.L., J.O.S., B.P.L.); and Harvard Medical School, Boston, Mass (D.C., N.R.).ORCID https://orcid.org/0000-0001-6270-0078
Nicholas ReidDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.L., A.S., D.P.M., E.J.F., M.D.L., J.O.S., B.P.L.); and Harvard Medical School, Boston, Mass (D.C., N.R.).ORCID https://orcid.org/0000-0003-3256-3986
Dexter P MendozaDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.L., A.S., D.P.M., E.J.F., M.D.L., J.O.S., B.P.L.); and Harvard Medical School, Boston, Mass (D.C., N.R.).ORCID https://orcid.org/0000-0001-7571-740X
Efrén J FloresDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.L., A.S., D.P.M., E.J.F., M.D.L., J.O.S., B.P.L.); and Harvard Medical School, Boston, Mass (D.C., N.R.).ORCID https://orcid.org/0000-0003-1398-0426
Matthew D LiDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.L., A.S., D.P.M., E.J.F., M.D.L., J.O.S., B.P.L.); and Harvard Medical School, Boston, Mass (D.C., N.R.).ORCID https://orcid.org/0000-0002-6207-4940
Jo-Anne O ShepardDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.L., A.S., D.P.M., E.J.F., M.D.L., J.O.S., B.P.L.); and Harvard Medical School, Boston, Mass (D.C., N.R.).ORCID https://orcid.org/0000-0003-1932-7620
Brent P LittleDepartment of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 (M.L., A.S., D.P.M., E.J.F., M.D.L., J.O.S., B.P.L.); and Harvard Medical School, Boston, Mass (D.C., N.R.).
Massachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate pulmonary vascular abnormalities at CT pulmonary angiography (CT-PE) in patients with coronavirus disease 2019 (COVID-19) pneumonia. MATERIALS AND

methodsIn this retrospective study, 48 patients with reverse-transcription polymerase chain reaction-confirmed COVID-19 infection who had undergone CT-PE between March 23 and April 6, 2020, in a large urban health care system were included. Patient demographics and clinical data were collected through the electronic medical record system. Twenty-five patients underwent dual-energy CT (DECT) as part of the standard CT-PE protocol at a subset of the hospitals. Two thoracic radiologists independently assessed all studies. Disagreement in assessment was resolved by consensus discussion with a third thoracic radiologist.

resultsOf the 48 patients, 45 patients required admission, with 18 admitted to the intensive care unit, and 13 requiring intubation. Seven patients (15%) were found to have pulmonary emboli. Dilated vessels were seen in 41 cases (85%), with 38 (78%) and 27 (55%) cases demonstrating vessel enlargement within and outside of lung opacities, respectively. Dilated distal vessels extending to the pleura and fissures were seen in 40 cases (82%) and 30 cases (61%), respectively. At DECT, mosaic perfusion pattern was observed in 24 cases (96%), regional hyperemia overlapping with areas of pulmonary opacities or immediately surrounding the opacities were seen in 13 cases (52%), opacities associated with corresponding oligemia were seen in 24 cases (96%), and hyperemic halo was seen in 9 cases (36%).

conclusionPulmonary vascular abnormalities such as vessel enlargement and regional mosaic perfusion patterns are common in COVID-19 pneumonia. Perfusion abnormalities are also frequently observed at DECT in COVID-19 pneumonia and may suggest an underlying vascular process.

Identifiers

PMID34036264
PMCPMC7307217
OpenAlexW3036320608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.