Evidence map›Paper›PMID 34035901›Full record

SynthesisF1000Research2020

Nitride oxide synthase 3 and klotho gene polymorphisms in the pathogenesis of chronic kidney disease and age-related cognitive impairment: a systematic review and meta-analysis.

Atma Gunawan, Jonny Karunia Fajar, Fredo Tamara, Aditya Indra Mahendra, Muhammad Ilmawan, Yeni Purnamasari, Dessy Aprilia Kartini, Eden Suryoiman Winoto, Efriko Septananda Saifillah, Dewi Sri Wulandari and 5 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in F1000Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Association of NOS3 rs1799983 Polymorphism with Cognitive Function in Patients with First Episode Depression.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Atma GunawanDivision of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
Jonny Karunia FajarBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.ORCID 0000-0002-0309-5813
Fredo TamaraBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
Aditya Indra MahendraBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.ORCID 0000-0003-0983-993X
Muhammad IlmawanFaculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.ORCID 0000-0002-9459-609X
Yeni PurnamasariFaculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.ORCID 0000-0001-5830-3571
Dessy Aprilia KartiniFaculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
Eden Suryoiman WinotoBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.ORCID 0000-0001-8427-5017
Efriko Septananda SaifillahBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
Dewi Sri WulandariBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
Pratista Adi KrisnaBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
Ema Dianita MayasariBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
Tri Wahyudi Iman DantaraBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.ORCID 0000-0001-5210-3405
Ramadi Satryo WicaksonoBrawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
Djoko Wahono SoeatmadjiDivision of Endocrinology and Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
University of Brawijaya · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cognitive DysfunctionRenal Insufficiency, ChronicAllelesGenotypeHumansOxidesOxidesage-related cognitive impairmentchronic kidney diseaseklothoNitride oxide synthase

Identifiers

PMID34035901
PMCPMC8112466
OpenAlexW3015486986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.